187722-67-4Relevant academic research and scientific papers
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy
Nozal, Vanesa,Martínez-González, Loreto,Gomez-Almeria, Marta,Gonzalo-Consuegra, Claudia,Santana, Paula,Chaikuad, Apirat,Pérez-Cuevas, Eva,Knapp, Stefan,Lietha, Daniel,Ramírez, David,Petralla, Sabrina,Monti, Barbara,Gil, Carmen,Martín-Requero, Angeles,Palomo, Valle,de Lago, Eva,Martinez, Ana
, p. 1585 - 1607 (2022/01/20)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease without any effective treatment. Protein TDP-43 is a pathological hallmark of ALS in both sporadic and familiar patients. Post-translational modifications of TDP-43 promote its aggre
Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase
Kurup, Sonali,McAllister, Bradley,Liskova, Pavlina,Mistry, Trusha,Fanizza, Anthony,Stanford, Dan,Slawska, Jolanta,Keller, Ulrich,Hoellein, Alexander
, p. 74 - 84 (2017/11/15)
Simultaneous inhibition of multiple kinases has been suggested to provide synergistic effects on inhibition of tumour growth and resistance. This study describes the design, synthesis and evaluation of 18 compounds incorporating a pyrrolo[2,3-d]pyrimidine
Heterocyclic ring-fused pyrimidine derivatives
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, (2016/01/12)
The present invention relates to heterocyclic ring-fused pyrimidine derivatives of formula (I) or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof, wherein Z and Y are as defined in the specification. Compounds of formula (I) are useful in the treatment of hyperproliferative diseases, such as cancers and acnes, in mammals:
