187725-48-0

Downstream Products

• 187725-46-8 (R)-(+)-3-acetoxy-2-(3-methoxyphenyl)-2-methyl-1-propanol 
• 187725-53-7 Acetic acid (S)-3-(tert-butyl-dimethyl-silanyloxy)-2-(3-methoxy-phenyl)-2-methyl-propyl ester 
• 163981-36-0 (S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol 

Relevant academic research and scientific papers

Asymmetric construction of benzylic quaternary carbons by lipase-mediated enantioselective transesterification of prochiral α,α-disubstituted 1,3-propanediols

The asymmetric differentiation by lipase-catalysed transesterification of prochiral α,α-disubstituted 1,3-propanediols 5 and 11 was accomplished in good enantiomeric excess and high chemical yield. The absolute configuration of the corresponding monoacetates (+)-2a and (-)-12a were determined by conversion into known key intermediates used in the synthesis of (-)-aphanorphine and (+)-eptazocine.