187725-53-7Relevant academic research and scientific papers
Asymmetric construction of benzylic quaternary carbons by lipase-mediated enantioselective transesterification of prochiral α,α-disubstituted 1,3-propanediols
Fadel, Antoine,Arzel, Philippe
, p. 283 - 291 (2007/10/03)
The asymmetric differentiation by lipase-catalysed transesterification of prochiral α,α-disubstituted 1,3-propanediols 5 and 11 was accomplished in good enantiomeric excess and high chemical yield. The absolute configuration of the corresponding monoacetates (+)-2a and (-)-12a were determined by conversion into known key intermediates used in the synthesis of (-)-aphanorphine and (+)-eptazocine.
Enzymatic asymmetrisation of prochiral α,α-disubstituted-malonates and -1,3-propanediols: Formal asymmetric syntheses of (-)-aphanorphine and (+)-eptazocine
Fadel, Antoine,Arzel, Philippe
, p. 371 - 374 (2007/10/03)
Formal asymmetric syntheses of (-)-aphanorphine and (+)-eptazocine are reported via the two key intermediate 3a and 3b obtained in 94-97% ee, from the readily available chirons (R)-5 and (R)-9. Which resulting from enzyme-catalysed asymmetrisation of prochiral α,α-disubstituted-1,3-propanediols and -malonates respectively.
