187748-60-3Relevant academic research and scientific papers
Columnar liquid-crystalline metallomacrocycles
Kawano, Shin-Ichiro,Ishida, Yukari,Tanaka, Kentaro
, p. 2295 - 2302 (2015)
We report synthesis of novel macrocyclic molecules and their metal complexes as well as their thermotropic columnar liquid-crystalline behavior. The macrocyclic ligands were prepared size-selectively based on dynamic covalent chemistry. X-ray study of a m
HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER
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Page/Page column 55, (2012/04/23)
An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.
Effects-driven chemical design: The acute toxicity of CO 2-triggered switchable surfactants to rainbow trout can be predicted from octanol-water partition coefficients
Arthur, Troy,Harjani, Jitendra R.,Phan, Lam,Jessop, Philip G.,Hodson, Peter V.
supporting information; experimental part, p. 357 - 362 (2012/04/10)
For both environmental protection and improved energy efficiency, CO 2-triggered switchable surfactants have been developed to change surface activity and solubility upon command. Surfactant activity is turned on by introduction of one atmosphere of CO2 and reversed by purging with air or nitrogen. These surfactants have numerous potential industrial applications related to their ability to stabilize and destabilize emulsions upon command. To assess their potential environmental impacts, we tested the acute toxicity of nine switchable surfactants to rainbow trout (Oncorhyncus mykiss) at pH ～8.0, typical of natural surface waters. The surfactants were synthesized in several variations, differing in the structure of the hydrophobic tail group, the hydrophilic head group, or both. A strong correlation between the log of the estimated octanol/water partition coefficients (log P) and the toxicity of eight switchable surfactants formed the basis of a structure-activity relationship that was used to design a ninth compound. That new compound had the lowest toxicity of all of the switchable surfactants tested. The effect of log P on acute toxicity was similar to that reported in the literature for other organic compounds. This model shows that despite the addition of varying functional groups, switchable surfactant toxicity remains largely dependent on log P and differs little from traditional non-switchable surfactants. The log P relationship developed provides a very useful tool for screening new compounds for acute toxicity.
A Synthesis of acetamidines
Harjani, Jitendra R.,Liang, Chen,Jessop, Philip G.
experimental part, p. 1683 - 1691 (2011/05/12)
The condensation of primary amine with N,N-dimethylacetamide dimethyl acetal yields amixture of acetamidine and imidate ester. The product distribution in this reaction depends on the temperature, solvent, and structure of the primary amine. It is possible to suppress the formation of imidate ester by performing the reaction in the presence of excess dimethyl amine, yielding acetamidine as the exclusive product. For acetamidines that cannot be purified either by crystallization or distillation, this new method is necessary for the generation of pure acetamidines in good yields.
