112-59-4 Hazards Identification
Pictogram(s):
Signal:
Danger
GHS Hazard Statements:
H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
Precautionary Statement Codes:
P264+P265, P280, P302+P352, P305+P354+P338, P317, P321, P362+P364, and P501
Hazard Classes and Categories:
Acute Tox. 4 *
Eye Dam. 1
Acute Tox. 4 (100%)
Eye Dam. 1 (100%)
Acute toxicity (ingestion) - category 4
Eye damage - category 1
Skin irritation - category 2
Acute toxicity (Dermal) - Category 4
Serious eye damage/eye irritation - Category 2A
Hazards Summary:
A skin and eye irritant; [CAMEO] Acute health effects are not expected unless workers are exposed to mist or heated liquid; [CHEMINFO] Dermal LD50 (rabbits) = 2000 mg/kg; In oral or dermal doses > 800-1000 mg/kg/day, causes CNS depression, liver and kidney injury, but no significant developmental toxicity; No effects on fertility at 1000 mg/kg/day; [Reference #1] See GLYCOL ETHERS.
112-59-4 Usage
Uses
Used in Coatings Industry:
2-(2-HEXYLOXYETHOXY)ETHANOL is used as a solvent for [application type] in the coatings industry for [application reason] its ability to dissolve and carry resins, which helps in the formation of a smooth and even coating.
Used in Degreasing Applications:
In the cleaning and maintenance sector, 2-(2-HEXYLOXYETHOXY)ETHANOL is used as a degreasing agent for [application type] its effectiveness in removing grease, oil, and dirt from various surfaces, making it a valuable component in cleaning solutions and degreasing processes.
Different applications in different industries may include its use as an emulsifier, wetting agent, or dispersant, depending on the specific requirements and properties needed.
Air & Water Reactions
Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid.
Reactivity Profile
Ethers, such as 2-(2-HEXYLOXYETHOXY)ETHANOL can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
Health Hazard
Exposure can cause irritation of eyes, nose and throat.
Fire Hazard
Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon dioxide and carbon monoxide, may be formed when involved in fire.
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 112-59-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 112-59:
(5*1)+(4*1)+(3*2)+(2*5)+(1*9)=34
34 % 10 = 4
So 112-59-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H22O3/c1-2-3-4-5-7-12-9-10-13-8-6-11/h11H,2-10H2,1H3
112-59-4Relevant academic research and scientific papers
Tcarkova,Belus’,Artyushin,Kharlamov,Bondarenko
, p. 2697 - 2701 (2015)
A series of acyclic symmetric quaternary ammonium chlorides Me2(HOCH2CH2)N+(CH2CH2O)nR Cl– (n = 1, R = n-C9H19; n = 2, R = n-C6H13; n = 3, R = n-C3H7) was synthesized by alkylation of the corresponding tertiary amines Me2N(CH2CH2O)nR with ethylene chlorohydrin in a two-phase system, using water as a solvent. The tertiary amines were synthesized in a heterogeneous system organic phase—aqueous phase, using an aqueous solution of Me2NH and a solid alkali. The intermediate monoethers of ethylene, diand triethylene glycol were obtained in high yield via a phase-transfer alkylation in dioxane, using solid KOH. The proton and carbon atom signals in the NMR spectra of the synthesized amines and ammonium chlorides were assigned based on the data of heteronuclear correlations (1H, 13C).
Combinatorial synthesis of PEG oligomer libraries
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Page/Page column 9, (2010/02/15)
A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.
Topical mosquito repellents VII: Alkyl triethylene glycol monoethers
Johnson,DeGraw,Engstrom,Skinner,Brown,Skidmore,Maibach
, p. 693 - 695 (2007/10/05)
Normal and branched chain aliphatic monoethers of triethylene glycol are effective topical mosquito repellents. In terms of duration of protection, they are generally superior to the corresponding diethylene glycol analogs, and some are superior to diethyltoluamide. The n heptyl monoether of triethylene glycol affords double the protection time of diethyltoluamide under controlled laboratory conditions, and appears to be a useful new mosquito repellent.
