187753-87-3 Usage
Uses
Used in Neuroscience Research:
BU 239 Hydrochloride is used as a research compound for investigating the binding and interaction of I2 receptors in the rat brain. Its application aids scientists in understanding the role of these receptors in cognitive functions, neurodegenerative diseases, and other brain-related disorders.
Used in Pharmaceutical Development:
As a competitive ligand for I2 receptors, BU 239 Hydrochloride can be utilized in the development of potential drugs targeting these receptors. This may lead to the creation of novel therapeutic agents for the treatment of neurological and psychiatric conditions associated with I2 receptor dysregulation.
Used in Radioligand Binding Assays:
BU 239 Hydrochloride is employed as a radioligand in binding assays to measure the affinity and selectivity of I2 receptors. This helps researchers to evaluate the potency and efficacy of new compounds designed to modulate these receptors, contributing to the advancement of drug discovery and development.
Biological Activity
High affinity ligand for the imidazoline I 2 binding site.
Check Digit Verification of cas no
The CAS Registry Mumber 187753-87-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,7,5 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 187753-87:
(8*1)+(7*8)+(6*7)+(5*7)+(4*5)+(3*3)+(2*8)+(1*7)=193
193 % 10 = 3
So 187753-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N4.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,7H,5-6H2,(H,12,13);1H
187753-87-3Relevant academic research and scientific papers
Yin, Zhiwei,Zhang, Zhongxing,Zhu, Juliang,Wong, Henry,Kadow, John F.,Meanwell, Nicholas A.,Wang, Tao
, p. 4919 - 4923 (2005)
Aryl aminoacetonitriles are oxidized by NiO2-H2O or MnO2 in the presence of a wide range of NH2-containing compounds to afford aryl amidines, presumably via iminium intermediates. A 'one-pot' procedure for the preparation of heteroaryl amidines from N-containing heteroaryl halides through a process comprising sequential SNAr substitution and oxidation has also been developed.
