187848-74-4

Upstream product

• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 

Downstream Products

• 187848-84-6 (2S,3R)-3-hydroxy-2-methyl-1,5-diphenylpent-4-en-1-one 
• 61878-73-7 3-hydroxy-2-methyl-1,3-diphenyl-propan-1-one 
• 283151-71-3 (2R,3R)-3-hydroxy-2-methyl-1,3-diphenylpropan-1-one 
• 187848-93-7 (2S,3S)-1,3-diphenyl-3-hydroxy-2-methyl-1-propanone 
• 71908-02-6 (2SR,3RS)-3-hydroxy-2-methyl-1,3-diphenylpropan-1-one 
• 71908-03-7 (2SR,3RS)-2-methyl-1,3-diphenyl-3-hydroxypropan-1-one 
• 625096-45-9 erythro-3-hydroxy-2-methyl-1,3-diphenyl-1-propanone 

Relevant academic research and scientific papers

Stereoselective aldol additions of achiral ethyl ketone-derived trichlorosilyl enolates

Methods for the preparation of geometrically defined enoxy(trichlorosilanes) derived from ethyl ketone enolates have been developed. The addition of enoxy(trichlorosilanes) (trichlorosilyl enolates) to aldehydes proceeds with good yields in the presence of catalytic amounts of chiral phosphoramides. The reaction of Z-trichlorosilyl enolates to aryl aldehydes affords aldol products with good to excellent diastereo- and enantioselectivities. Phosphoramide-catalyzed aldol additions lacked substrate generality providing modest selectivities with unsaturated and aliphatic aldehydes. In all cases, the phosphoramide-catalyzed aldol addition of E-trichlorosilyl enolates to aldehydes provided good yields with moderate to good stereoselectivities.