187849-05-4

Upstream product

• 187849-02-1 5-(3-[1,3]Dioxolan-2-yl-propyl)-thiophene-2-carboxylic acid benzyl ester 
• 187849-03-2 5-(3-Carboxy-propyl)-thiophene-2-carboxylic acid benzyl ester 
• 187849-01-0 5-(3-[1,3-dioxolan-2-yl]propyl)-2-thiophene carboxylic acid 
• 100-39-0 benzyl bromide 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 
• 187849-04-3 5-[3-(2,2-Dimethyl-propionyloxycarbonyl)-propyl]-thiophene-2-carboxylic acid benzyl ester 

Downstream Products

• 187849-07-6 5-[(S)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(benzyloxycarbonylamino-methyl)-4-oxo-butyl]-thiophene-2-carboxylic acid benzyl ester 
• 187849-12-3 2-[(R)-2-(Benzyloxycarbonylamino-methyl)-4-(5-benzyloxycarbonyl-thiophen-2-yl)-butyl]-malonic acid diethyl ester 
• 187849-11-2 5-[(S)-3-(Benzyloxycarbonylamino-methyl)-4-methanesulfonyloxy-butyl]-thiophene-2-carboxylic acid benzyl ester 
• 187849-09-8 5-((S)-4-Benzyloxycarbonylamino-3-hydroxymethyl-butyl)-thiophene-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of dideazafolate antitumor agents via amidomethylation of nonracemic oxazolidinone imidates, synthesis of LY309887, a cytotoxic dideazafolate analog related to lometrexol

The asymmetric synthesis of LY309887, a cytotoxic dideazatetrahydrofolate analog related to lometrexol, has been accomplished via an application of diastereoselective amidomethylation of a chiral titanium (IV) acyloxazolidinone enolate.