187870-25-3

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid 

Downstream Products

• 1027402-62-5 C₁₇H₁₈ClNO₄ 
• 187870-40-2 6-(4-chlorophenyl)-5,6,7,8-tetrahydroindolizin-8-one 
• 1027508-88-8 6-(4-Chloro-phenyl)-6,7-dihydro-5H-indolizin-8-ylideneamine 
• 187870-30-0 N-[3-(4-chlorophenyl)-4-(pyrrol-1-yl)butyryl]pyrrolidine 
• 187870-71-9 8-N-benzylidenamino-6-(4-chlorophenyl)-5,6,7,8-tetrahydroindolizine 

Relevant academic research and scientific papers

Pharmacological evaluation of new baclofen derivatives

The synthesis and in-vivo central pharmacological properties, in particular antinociceptive activity, of some new baclofen derivatives is described. The delayed antinociceptive activity of the N-trifluoroacetyl analogue of baclofen is also characterized.

A Convenient Route to New Phenyltetrahydroindolizines

Synthesis of new 6-(4-chlorophenyl)-5,6,7,8-tetrahydroindolizines was achieved starting from 4-amino-3-(4-chlorophenyl)butyric acid (Baclofen). The chemical pathway, involving a Clauson-Kaas reaction and a subsequent cyclization, led to an iminium salt wh