187870-29-7

Upstream product

• 119-61-9 benzophenone 
• 502183-32-6 1-methyl-3,3,3',3'-tetrakis(trifluoromethyl)-1,1'-spirobi[1,3-dihydro-2,1λ⁵-benzoxaphosphole] 
• 187870-00-4 C₂₅H₁₅F₁₂O₂PS 
• 718-64-9 1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol 

Relevant academic research and scientific papers

Hexacoordinate phosphates bearing an oxaphosphetane ring: Characterization and stereomutation

The reaction of a β-hydroxyspirophosphorane (4) bearing Martin ligands with base was found to give a hexacoordinate phosphate (isomer 1), which eventually isomerized to another phosphate (isomer 2). Kinetic examination of the stereomutation process implied that it involved P-O bond heterolysis as the rate determining step. This was assumed to be followed by pseudorotation and P-O bond formation.

Synthesis of thermolysis of hexacoordinate 1,2-oxaphosphetanides

β-Hydroxyalkylphosphoranes containing two Martin ligands were prepared by reduction of the corresponding phenylthiomethylphosphorane with lithium naphthalenide, followed by the reaction with carbonyl compounds. Treatment of the β-hydroxyalkylphosphoranes with KH in the presence of 18-crown-6 gave a mixture of stereoisomers of the corresponding hexacoordinate 1,2-oxaphosphetanides stable in solution at room temperature. Upon heating, the adducts of benzophenone derivatives gave the corresponding benzophenones, while a hexafluoroacetone adduct afforded the corresponding olefin.