187875-14-5Relevant academic research and scientific papers
Drug resistance modulation in staphylococcus aureus, a new biological activity for mesoionic hydrochloride compounds
De Oliveira, Cledualdo Soares,Falcao-Silva, Vivyanne Dos Santos,Siqueira-Junior, Jose Pinto,Harding, David Peter,Lira, Bruno Freitas,Lorenzo, Jorge Goncalo Fernandes,Barbosa-Filho, Jose Maria,De Athayde-Filho, Petrnio Filgueiras
, p. 2023 - 2031 (2011/05/11)
Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1, 3,4- thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1, 3,4- thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenylthiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 μg/mL, favourably modulated the antibiotic activity of tetracycline by 16- and 32-fold, respectively (MIC), and that of erythromycin by 4-fold.
