187876-97-7

Upstream product

• 187876-91-1 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-1-trimethylsilyloxy-1-cyclopentene 
• 141389-79-9 (3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopentanone 

Downstream Products

• 187877-01-6 (1R,2S,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentanol 
• 187877-05-0 (1S,2R,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentanol 
• 187878-48-4 9-[(1S,2R,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-6-chloro-9H-purine 
• 187877-82-3 9-[(1R,2R,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-6-chloro-9H-purine 
• 187877-62-9 9-[(1S,2S,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-6-chloro-9H-purine 
• 187878-12-2 9-[(1R,2S,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-6-chloro-9H-purine 
• 187877-40-3 Benzoic acid (1R,2R,3S,4S)-3,4-bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl ester 
• 187877-34-5 Benzoic acid (1S,2S,3S,4S)-3,4-bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl ester 
• 187877-75-4 9-[(1S,2S,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-6-chloro-9H-purin-2-ylamine 
• 187877-86-7 9-[(1R,2R,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-9H-purin-6-ylamine 
• 187877-70-9 9-[(1S,2S,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-9H-purin-6-ylamine 
• 187878-17-7 9-[(1R,2S,3S,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-2-fluoro-cyclopentyl]-9H-purin-6-ylamine 
• 187877-56-1 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-1S-azido-2R-fluorocyclopentane 
• 187877-47-0 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-1R-azido-2R-fluorocyclopentane 

Relevant academic research and scientific papers

Synthesis of novel fluoro carbocyclic purine nucleoside analogues

The synthesis of four isomerically pure fluoro-carbocyclic adenosine and guanosine analogues is described.

Synthesis of carbocyclic 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl nucleoside analogues as potential inhibitors of HIV and HSV

The synthesis of four isomerically pure fluoro-carbocyclic adenosine and guanosine analogues is described. The 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-2-fluoropentan- 1-ol derivatives 22, 23, 24 and 25 synthesised from enantiomerically pure 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-cyclopentanone (18), were coupled with chloropurines using the Mitsunobu procedure to give 10, 11, 12, 14 and 16 or converted to their corresponding 1-amino derivatives, from which the fluoro-carbocyclic guanosine analogues 13, 15 and 17 were prepared. Compounds 10-17 were evaluated as potential anti-viral agents but were found to be inactive.