187877-87-8

Upstream product

• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 

Downstream Products

• 221385-53-1 5-hydroxy-7-methoxyflavonone 
• 59887-91-1 5,7-dimethoxy-4H-chromen-4-one 
• 480-37-5 pinostrobin 
• 1036-72-2 Pinocembrin dimethyl ether 
• 22044-59-3 3-(3',4'-methylendioxyphenyl)-5,7-dimethoxy-4H-chromen-4-one 
• 65893-94-9 3-(3',4'-bis(3-methylbut-2-enyloxy)phenyl)-5,7-dimethoxy-4H-chromen-4-one 

Relevant academic research and scientific papers

MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF

The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).

Highly enantioselective and efficient synthesis of flavanones including pinostrobin through the rhodium-catalyzed asymmetric 1,4-addition

An efficient synthesis of bioactive chiral flavanones (1) was achieved through the αh-catalyzed asymmetric 1,4-addition of arylboronic acid to chromone. The reaction in toluene proceeded smoothly at room temperature in the presence of 0.5% Rh catalyst with electron-poor chiral diphosphine MeO-F 12-BIPHEP. In this reaction, the 1,2-addition to (S)-1 frequently occurred to yield (2S,4α)-2,4-diaryl-4-chromanol as a byproduct, which could be reduced by changing the reaction solvent to CH2C 12 to deactivate the Rh catalyst (3% required).