22044-59-3

Basic information

• Product Name: 3-(1,3-Benzodioxol-5-yl)-5,7-dimethoxy-4H-1-benzopyran-4-one
• Synonyms: 3-(1,3-Benzodioxol-5-yl)-5,7-dimethoxy-4H-1-benzopyran-4-one;Derrustone
• CAS NO: 22044-59-3
• Molecular Weight: 0
• Mol File: 22044-59-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(1,3-Benzodioxol-5-yl)-5,7-dimethoxy-4H-1-benzopyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-Benzodioxol-5-yl)-5,7-dimethoxy-4H-1-benzopyran-4-one(22044-59-3)
• EPA Substance Registry System: 3-(1,3-Benzodioxol-5-yl)-5,7-dimethoxy-4H-1-benzopyran-4-one(22044-59-3)

Safety Data

• Hazardous Substances Data: 22044-59-3(Hazardous Substances Data)

Upstream product

• 187877-87-8 3-dimethylamino-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 
• 4439-02-5 3,4-methylenedioxyphenylacetonitrile 
• 39548-98-6 2-(benzo[d][1,3]dioxol-5-yl)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 108-73-6 3,5-dihydroxyphenol 
• 84161-84-2 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(benzo[d] [1,3]dioxol-5-yl)prop-2-en-1-one 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 859440-74-7 5,7-dimethoxy-3',4'-methylenedioxyflavanone 
• 22044-73-1 2-benzo[1,3]dioxol-5-yl-1-(2-hydroxy-4,6-dimethoxy-phenyl)-ethanone 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 65893-94-9 3-(3',4'-bis(3-methylbut-2-enyloxy)phenyl)-5,7-dimethoxy-4H-chromen-4-one 
• 529-60-2 5,3'4'-trihydroxy-7-methoxyisoflavone 

Relevant articles and documents

MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF

The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).

Synthesis of isoflavones containing naturally occurring substitution pattern by oxidative rearrangement of respective flavanones using thallium(III) p-tosylate

Claisen condensation of substituted 2′-hydroxyacetophenones 1a-c with aromatic aldehydes affords respective substituted 2′-hydroxychalcones 2a-n which on base catalyzed cyclization in pyridine:methanol:water (1:1:1) give respective flavanones 3a-n. The oxidative rearrangement of flavanones with thallium(III) p-tosylate furnishes respective isoflavones 4a-n in overall 62-72% yields starting from 1. The present methodology has been successfully applied for the synthesis of naturally occurring isoflavones such as di-O-methyldaidzein 4a, cabruvin 4b, pseudobabtigenin methylether 4d, 5,7-dimethoxyisoflavone 4f, 5,7,4′-trimethoxyisoflavone 4g, derrustone 4i, 7,8,3′,4′- tetramethoxyisoflavone 41, purpuranin-A 4m and 7,8,3′,4′,5′- pentamethoxyisoflavone 4n and thus the first synthesis of 4n is reported.