187887-01-0Relevant articles and documents
A new approach to 1,4-oxazines and 1,4-oxazepines via base-promoted exo mode cyclization of alkynyl alcohols: Mechanism and DFT studies
Vandavasi, Jaya Kishore,Hu, Wan-Ping,Chen, Hsing-Yin,Senadi, Gopal Chandru,Chen, Chung-Yu,Wang, Jeh-Jeng
, p. 3134 - 3137 (2012/08/07)
A new approach was developed to synthesize 1,4-oxazine and 1,4-oxazepine derivatives without solvent and metal. Regioselective cyclization occurred to afford exclusively the exo-dig product, and stereochemistry was studied by circular dichroism and specif
Novel 1,3-diene synthesis from alkyne and ethylene by ruthenium- catalyzed enyne metathesis
Kinoshita, Atsushi,Sakakibara, Norikazu,Mori, Miwako
, p. 8155 - 8167 (2007/10/03)
A novel 1,3-diene synthetic method from alkyne and ethylene was developed using ruthenium-catalyzed enyne metathesis. The reaction procedure is very simple: A CH2Cl2 solution of alkyne was stirred at room temperature under ethylene gas (1 atm.) in the presence of a catalytic amount of ruthenium benzylidene complex. The yield was good and the conversion yield was high. Dienes having functional groups such as a keto-carbonyl group, silyloxy group, ester, and ketal were synthesized from the corresponding alkynes and ethylene. In this reaction, the alkyne having a hetero atom at the propargylic position gave a good result and ether oxygen or amine nitrogen that coordinate strongly to the ruthenium catalyst prevents the reaction.
Novel synthesis of heterocycles using nickel(0)-catalyzed [2+2+2] cocyclization: Catalytic asymmetric synthesis of isoindoline and isoquinoline derivatives
Sato, Yoshihiro,Nishimata, Toyoki,Mori, Miwako
, p. 443 - 457 (2007/10/03)
A nickel(0)-catalyzed asymmetric [2+2+2] cocyclization has been realized for the first time. That involves conceptually new enantiotopic group selective formation of the nickelacyclopentadiene (18) and produces the isoindoline (26a) (73percent ee, 78perce
NEW SYNTHESIS OF PIPERIDINE DERIVATIVES VIA THE CHROMACYCLOBUTANE
Watanuki, Susumu,Mori, Miwako
, p. 679 - 682 (2007/10/02)
Piperidine derivatives were synthesized from the enynes and Fischer chromium carbene complex via chromacyclobutanes in moderate yields and the reaction course was controlled by the substituents on the double bond of the enynes.