58963-78-3Relevant academic research and scientific papers
METHODS AND COMPOSITIONS FOR MODULATING SPLICING
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Paragraph 0620; 0762, (2020/08/22)
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.
IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS
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Paragraph 00165, (2020/06/05)
The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.
In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors
Tasker, Nikhil R.,Rastelli, Ettore J.,Blanco, Isabella K.,Burnett, James C.,Sharlow, Elizabeth R.,Lazo, John S.,Wipf, Peter
supporting information, p. 2448 - 2466 (2019/03/06)
A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones to produce 7-iminothieno[3,2-c]pyridine-4,6(5H,7H)-diones has been developed, utilizing ambient air as the sole reactant. N-H Imines are formed as the major products, and excellent functional group tolerance and conversion on gram-scale without the need for chromatographic purification allow for facile late-stage diversification of the aminothienopyridinone scaffold. Several analogs exhibit potent in vitro inhibition of the cancer-associated protein tyrosine phosphatase PTP4A3, and the SAR supports an exploratory docking model.
Tetrazole amide derivatives of heterocyclic alkenyl acid and their use as antiallergic substances
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, (2008/06/13)
Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula STR1 in which Y=NH, O or S when m=1; Y=N when m=2; m=1 or 2; l=0 or 4; R=H, C1-4 alkyl, Cl, Br, CF3, CH2 OCOCH3, or OCH2 -Ph; R1 =H, alkaline metal or alkaline earth metal, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Such derivatives possess high antiallergic activity.
Tetrazole amide derivatives of heterocyclic alkenyl acids and their use as antiallergic substances
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, (2008/06/13)
Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula (I): in which, Y = NH, O or S when m = 1;, Y = N when m = 2;, m = 1 or 2;, l = 0 or 4;, R = H, C1 4 alkyl, Cl, Br, CF3, CH2OCOCH3, or OCH2-Ph;, R1 = H, alkaline metal or alkaline earth metal;, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Said derivatives possess high antiallergic activity.
