18791-99-6

Basic information

• Product Name: 4-Bromothiophene-2-carbonitrile
• Synonyms: 4-Bromo-2-cyanothiophene;4-Bromothiophene-2-carbonitrile;4-Bromothiophene-2-carbonitrile 98%;2-Thiophenecarbonitrile,4-broMo-;4-Bromothiophene-2-carbonitrile98%
• CAS NO: 18791-99-6
• Molecular Formula: C₅H₂BrNS
• Molecular Weight: 188.04508
• Product Categories: blocks;Bromides;Carboxes;Heterocycles
• Mol File: 18791-99-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 47.0 to 51.0 °C
• Boiling Point: 230.383 °C at 760 mmHg
• Flash Point: 93.133 °C
• Appearance: /
• Density: 1.826 g/cm³
• Vapor Pressure: 0.066mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Bromothiophene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromothiophene-2-carbonitrile(18791-99-6)
• EPA Substance Registry System: 4-Bromothiophene-2-carbonitrile(18791-99-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 18791-99-6(Hazardous Substances Data)

Usage

General Description

4-Bromothiophene-2-carbonitrile is a chemical compound with the molecular formula C6H3BrNOS. It is a brominated derivative of thiophene with a cyano group attached to the 2-position of the ring. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. 4-Bromothiophene-2-carbonitrile is known for its use as a building block in the creation of various complex organic molecules due to its unique structural properties. Additionally, it is an important reagent in organic synthesis and is widely used in research laboratories and chemical manufacturing industries.

InChI:InChI=1/C5H2BrNS/c6-4-1-5(2-7)8-3-4/h1,3H

Upstream product

• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 67-56-1 methanol 
• 83933-17-9 4-bromothiophene-2-carboxamide 
• 179898-22-7 7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline 
• 31767-01-8 4-bromothiophene-2-carbaldehyde oxime 

Downstream Products

• 1312185-49-1 4,5,6,7-tetraphenylbenzo[b]thiophene-2-carbonitrile 
• 1272674-70-0 ethyl 5-chloro-3-(2-cyanoacetamido)-1-(4-(5-cyanothiophen-3-yl)phenyl)-1H-pyrrole-2-carboxylate 
• 304857-74-7 4-(2,4,4-Trimethyl-1,4-dihydro-2H-3,1-benzoxazin-6-yl)thiophene-2-carbonitrile 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

QUINOLINE DERIVATIVES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-RELATED DISEASES AND DISORDERS

Provided herein are quinolines, e.g., a compound of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure-activity relationship of the aryl region

The structure-activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-gp liability compared to benzyl amine analog 1.