187932-52-1Relevant academic research and scientific papers
COMPOUND FOR BORON NEUTRON CAPTURE THERAPY FOR AMYLOID β DISEASES
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, (2020/06/05)
PROBLEM TO BE SOLVED: To provide a boron carrier compound having high binding specificity to an amyloid β protein, high permeability through the blood brain barrier, and a retention property in senile plaques in the brain, while having a property less lik
COMPOSITION FOR AMYLOID-ASSOCIATED DISEASE DIAGNOSIS
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Page/Page column 5; 32; 44; 51, (2010/11/28)
A composition for diagnosing amyloid-related diseases, which comprises a flavone derivative, a chalcone derivative, a styrylchromone derivative, or a coumarin derivative, is provided. These compounds have high binding specificity to an amyloid β protein,
Efficient synthesis of nitroflavones by cyclodehydrogenation of 2prime;-hydroxychalcones and by the Baker-Venkataraman method
Barros, Ana I. R. N. A.,Silva, Artur M. S.
, p. 1505 - 1528 (2007/10/03)
Several nitroflavone derivatives were synthesized by cyclodehydrogenation of 2′-hydroxychalcones and by the Baker-Venkataraman approach, starting from 2′-hydroxyacetophenones and benzoic acid derivatives. Nitroflavones synthesised by the first synthetic a
Radioiodinated flavones for in vivo imaging of β-amyloid plaques in the brain
Ono, Masahiro,Yoshida, Naoko,Ishibashi, Kenichi,Haratake, Mamoru,Arano, Yasushi,Mori, Hiroshi,Nakayama, Morio
, p. 7253 - 7260 (2007/10/03)
In vivo imaging of β-amyloid (Aβ) peptide aggregates in the brain may lead to early detection of Alzheimer's disease (AD) and monitoring of the progression and effectiveness of AD treatment. The purpose of this study was to develop novel amyloid imaging a
Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor
Marder, Mariel,Zinczuk, Juan,Colombo, Maria I.,Wasowski, Cristina,Viola, Haydee,Wolfman, Claudia,Medina, Jorge H.,Ruveda, Edmundo A.,Paladini, Alejandro C.
, p. 2003 - 2008 (2007/10/03)
A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.
