18794-94-0

Basic information

• Product Name: Butanoic acid, 2-[2-(4-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester
• Synonyms: Butanoic acid, 2-[2-(4-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester
• CAS NO: 18794-94-0
• Molecular Formula: C₁₃H₁₆N₂O₄
• Molecular Weight: 264.27714
• Mol File: 18794-94-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Butanoic acid, 2-[2-(4-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[2-(4-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester(18794-94-0)
• EPA Substance Registry System: Butanoic acid, 2-[2-(4-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester(18794-94-0)

Safety Data

• Hazardous Substances Data: 18794-94-0(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 132577-10-7 4-[(2-Methoxy-phenyl)-hydrazono]-5-methyl-2-phthalazin-1-yl-2,4-dihydro-pyrazol-3-one 
• 132784-04-4 5-Cyano-1-(2-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 
• 1395469-21-2 4-(2-(2-methoxyphenyl)hydrazono)-1-(4-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)thiazol-2-yl)-3-methyl-1H-pyrazol-5(4H)-one 
• 1493471-97-8 2-[1-(4-isobutylphenyl)ethyl]-5-methyl-4-[2-(2-anisyl)hydrazinylidene]-2,4-dihydro-3H-pyrazol-3-one 
• 1456804-36-6 4-(2-(2-methoxyphenylhydrazono))-1-(6-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-3-methyl-1H-pyrazol-5(4H)-one 
• 1309479-19-3 C₁₈H₁₈N₄O₄S 
• 132784-14-6 5-Cyano-1-(2-methoxy-phenyl)-4-[(E)-2-(4-methoxy-phenyl)-vinyl]-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 
• 132784-16-8 5-Cyano-1-(2-methoxy-phenyl)-6-oxo-4-((E)-2-thiophen-2-yl-vinyl)-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 
• 132784-12-4 5-Cyano-1-(2-methoxy-phenyl)-6-oxo-4-((E)-styryl)-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 
• 132784-30-6 5-Acetylamino-3-(2-methoxy-phenyl)-4-oxo-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester 
• 132807-46-6 5-Acetylamino-4-oxo-3-o-tolyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester 
• 132807-45-5 5-Amino-3-(2-methoxy-phenyl)-4-oxo-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester 
• 132784-29-3 ethyl 5-amino-4-oxo-3-(o-tolyl)-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 
• 132784-20-4 1-(2-Methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Type II diabetes-related enzyme inhibition and molecular modeling study of a novel series of pyrazolone derivatives

Inhibitors of alpha-Amylase are targets for the development of novel drugs for the treatment of diabetes and obesity. Alpha amylase is an enzyme which increases the bio availability of glucose in the blood. Hence, the inhibition effects of alpha amylase of 2-[1-(4-isobutylphenyl)ethyl]-5-methyl-4-[2-(aryl- substituted)hydrazinylidene]-2,4-dihydro-3H-pyrazol-3-one (4a-l) were investigated, among them compounds 4d, 4f, 4a, and 4g have displayed good inhibitory activity. The compounds with significant results were further evaluated for their molecular modeling study using in silico method. The new series of compounds were synthesized by solvent-free microwave irradiation method and were characterized by spectral and analytical data.

Synthesis, characterization and antibacterial screening of new pyrazole and pyrazoline-5-one derivatives

A series of N′-(p-toluene sulphonyl)-3-methyl-4-(substituted arylhydrazono)-2-pyrazoline-5-ones and N′-(2-hydroxybenzoyl)-3,5-dimethyl- 4-(substituted arylazo)pyrazoles have been synthesized and characterized by chemical analysis, IR and 1H NMR spectral data. The compounds have been screened for antibacterial activity against Staphylococcus aureus and Escherichia coli.