187944-42-9Relevant academic research and scientific papers
Convenient diastereospecific synthesis of a rociverine precursor and its resolution by lipase-catalyzed transesterification
Di Bussolo, Valeria,Catelani, Giorgio,Mastrorilli, Ettore,Di Bugno, Cristina,Giorgi, Raffaello
, p. 3585 - 3592 (2007/10/03)
(±)-1-Cyclohexyl-c-2-hydroxymethyl-r-1-cyclohexanol 3, a precursor of the antimuscarinic drug Rociverine 1, was obtained diastereospecifically in very high yield, from the Grignard reaction between C6H11MgCl and an appropriately protected 2-hydroxymethyl)cyclohexanone. The preparation of enantiomerically enriched cis diol (+)-(1R, 2S-)-3 and the corresponding 2-acetoxymethyl derivative (+)-(1S,2R)-12 was achieved by lipase PPL-catalyzed transesterification of racemic diol (±)-3.
