187949-90-2

Basic information

• Product Name: 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
• Synonyms: SALOR-INT L252034-1EA;RARECHEM AL BO 0714;5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID;BUTTPARK 23\09-45;5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole;5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole, 1-(5-Amino-4-carboxy-1H-pyrazol-1-yl)-4-fluorobenzene
• CAS NO: 187949-90-2
• Molecular Formula: C₁₀H₈FN₃O₂
• Molecular Weight: 221.19
• Mol File: 187949-90-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(187949-90-2)
• EPA Substance Registry System: 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID(187949-90-2)

Safety Data

• Hazardous Substances Data: 187949-90-2(Hazardous Substances Data)

Usage

General Description

5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID is a chemical compound that belongs to the class of pyrazole carboxylic acids. It consists of a pyrazole ring with an amino group at position 5 and a carboxylic acid group at position 4, as well as a fluorophenyl substituent. 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals due to its structural features and potential pharmacological properties. It may also have utility as an intermediate in the synthesis of other compounds with related structures and properties. The chemical and biological properties of 5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID make it a subject of interest for further research and exploration in various fields of science and technology.

Upstream product

• 138907-68-3 ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 371-14-2 4-fluorophenylhydrazine 

Downstream Products

• 960249-78-9 5-amino-N-[2-(aminomethyl)-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase

The design and synthesis of novel multi-substituted benzo-indole pyrazole Schiff base derivatives of potent DNA gyrase inhibitory activity were the main aims of this study. All the novel synthesized compounds were examined for their antibacterial activities against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella. In addition, we selected 20 compounds for the in vitro antibacterial activities assay of 6 drug-resistant bacteria strains. The result revealed compound 8I-w exhibited excellent antibacterial activity against 4 drug-resistant E. coli bacteria strains with IC50 values of 7.0, 17.0, 13.5, and 1.0 μM, respectively. In vitro enzyme inhibitory assay showed that compound 8I-w displayed potent inhibition against DNA gyrase with IC50 values of 0.10 μM. The molecular docking model indicated that compounds 8I-w can bind well to the DNA gyrase by interacting with various amino acid residues. This study demonstrated that the compound 8I-w can act as the most potent DNA gyrase inhibitor in the reported series of compounds and provide valuable information for the commercial DNA gyrase inhibiting bactericides.

SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS

The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)