187977-44-2

Basic information

• Product Name: Toluene-4-sulfonic acid 6-thiazolidin-3-yl-hexyl ester
• CAS NO: 187977-44-2
• Molecular Weight: 343.511
• Mol File: 187977-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid 6-thiazolidin-3-yl-hexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid 6-thiazolidin-3-yl-hexyl ester(187977-44-2)
• EPA Substance Registry System: Toluene-4-sulfonic acid 6-thiazolidin-3-yl-hexyl ester(187977-44-2)

Safety Data

• Hazardous Substances Data: 187977-44-2(Hazardous Substances Data)

Upstream product

• 504-78-9 1,3-thiazolidine 
• 4672-50-8 1,6-bis(p-toluenesulfonyloxy)hexane 

Relevant articles and documents

Synthesis and α1-antagonist activity of new prazosin- and benextramine-related tetraamine disulfides

Tetraamine disulfides 1-10 were designed by combining the structural features of benextramine, an irreversible α1/α2-adrenoceptor antagonist, and prazosin, a selective competitive α1-antagonist. Their biological profile was assessed by functional and binding assays. In rat vas deferens functional experiments, tetraamine disulfides 1-10 displayed a marked selectivity at α1-adrenoceptors. Furthermore, they acted as competitive antagonists at α1-adrenoceptors and weak noncompetitive (irreversible) antagonists at α2-adrenoceptors. In binding assays, performed at α1-adrenoceptors of rat liver (α(1B)) and submaxillary gland (α(1A)), compound 5 showed an 11-fold selectivity for α(1B)-adrenoceptors in contrast to both prazosin and benextramine, which were not selective or selective for the α(1A)-subtype respectively.