4672-50-8

Upstream product

• 629-11-8 1,6-hexanediol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 10125-18-5 1,6-diphenoxyhexane 
• 5368-74-1 1,12-diphenyldodecane 
• 73992-40-2 1,12-Diphenyl-<3,3,10,10-D4>dodecan 
• 21964-51-2 hexadeca-1,15-diene 
• 77450-07-8 1,7-bis(p-tolylsulfonyl)-1,4,7-triazacyclotridecane 
• 77429-95-9 1,7,14,20-tetrakis(p-tolylsulfonyl)-1,4,7,14,17,20-hexaazacyclohexacosane 
• 1607-79-0 N,N'-di-p-tolyl-hexanediyldiamine 
• 120238-35-9 1-p-tolylazepane 
• 172655-85-5 C₁₅₂H₁₅₂O₂₄ 
• 187977-44-2 Toluene-4-sulfonic acid 6-thiazolidin-3-yl-hexyl ester 
• 112116-24-2 3,3'-[hexane-1,6-diylbis(oxy)]dibenzaldehyde 
• 299434-00-7 C₃₂H₄₂O₈ 
• 299434-13-2 C₃₂H₄₂O₈ 
• 155095-69-5 1,1'-(1,6-hexanediyl)bis[2-methoxybenzene] 

Relevant academic research and scientific papers

Design and Synthesis of Novel Dimeric Morphinan Ligands for κ and μ Opioid Receptors

A novel series of morphinans were synthesized, and their binding affinity at and functional selectivity for μ, δ, and κ opioid receptors were evaluated. These dimeric ligands can be viewed as dimeric morphinans, which were formed by coupling two identical

Aggregation-induced emission based on a fluorinated macrocycle: visualizing spontaneous and ultrafast solid-state molecular motions at room temperature: via F?F interactions

We for the first time report the efficient construction of novel tetraphenethylene (TPE)-based macrocycles with various mechanofluorochromism (MFC) behaviors involving solid-state molecular motions. We were able to facilely regulate the diverse solid-stat

Tetrastyrene macrocyclic compound with force-induced fluorescence color-changing performance and synthesis method and application thereof

The invention discloses a tetrastyrene macrocyclic compound with force-induced fluorescence color changing performance. The compound is connected with an alkyl chain structural unit through the strongfluorescence property of the tetrastyrene macrocyclic c

Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity

A library of dimers and heterodimers of both enantiomers of 2-O-alkylated iminoxylitol derivatives has been synthesised and evaluated on β-glucocerebrosidase (GCase), the enzyme responsible for Gaucher disease (GD). Although the objective was to target simultaneously the active site and a secondary binding site of the glucosidase, the (-)-2-iminoxylitol moiety seemed detrimental for imiglucerase inhibition and no significant enhancement was obtained in G202R, N370S and L444P fibroblasts. However, all compounds having at least one (+)-2-O-alkyl iminoxylitol are GCase inhibitors in the nano molar range and are significant GCase activity enhancers in G202R fibroblats, as confirmed by a decrease of glucosylceramide levels and by co-localization studies.

Ionic liquid brush as an efficient and reusable heterogeneous catalytic assembly for the tosylation of phenols and alcohols in neat water

A very efficient and reusable heterogeneous ionic liquid brush assembly was developed. The catalyst exhibits high catalytic activity for the tosylation of phenols and alcohols in neat water. Moreover, the catalyst shows outstanding stability and reusability, and it can be simply and effectively recovered and reused five times without noticeable loss of catalytic activity.

Synthesis and recognition properties of calix[4]arene semitubes as ditopic hosts for: N -alkylpyridinium ion pairs

A series of calix[4]arene semitubes (4a-c) having alkyl bridging spacers of different lengths and flexibilities on their lower rim was synthesised and characterised in solution and in the solid state by 1H NMR spectroscopy and X-ray crystallogr

Click reaction based synthesis, antimicrobial, and cytotoxic activities of new 1,2,3-triazoles

Three-motif pharmacophoric models 20a-e and 21-25 were prepared in good yields by CuAAC of two azido substrates 2 and 11 with seven terminal acetylenic derivatives including chalcones 17a-e, theophylline 18 and cholesterol 19. The structure of these compounds was elucidated by NMR, MS, IR spectroscopy and micro analyses. This series was screened as antimicrobial and cytotoxic agents in vitro. Most derivatives showed appreciable antibacterial activity, but they displayed weak cytotoxic, and antifungal activities. Notably, conjugate 25 (cream of the crop) was found to be more active than Ampicillin against Escherichia coli and Staphylococcus aureus and showed appreciable antifungal and cytotoxic activities as well.

Synthesis of [18F]-labeled (6-fluorohexyl)triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomography

Lipophilic cations such as phosphonium salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes and accumulate in mitochondria in response to the negative inner-transmembrane potentials. Thus, as newly developed noninvasive imagi

Reduction-degradable linear cationic polymers as gene carriers prepared by Cu(I)-catalyzed azide-alkyne cycloaddition

Linear reduction-degradable cationic polymers with different secondary amine densities (S2 and S3) and their nonreducible counterparts (C2 and C3) were synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) step-growth polymerization of the dia

A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression

We recently reported a new positron emission tomography (PET) reporter gene, namely, varicella-zoster virus thymidine kinase (VZV-tk) in combination, with carbon-11 or fluorine-18 labeled m-alkoxyphenyl bicyclic nucleoside analogues (BCNAs) as PET reporte