18800-35-6

Basic information

• Product Name: 1-(2-bromoethoxy)-2,4-dimethylbenzene
• Synonyms: 1-(2-bromoethoxy)-2,4-dimethylbenzene;UKRORGSYN-BB BBV-078794;1-(2-bromoethoxy)-2,4-dimethylbenzene(SALTDATA: FREE)
• CAS NO: 18800-35-6
• Molecular Formula: C₁₀H₁₃BrO
• Molecular Weight: 229.11
• Mol File: 18800-35-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 276.829°C at 760 mmHg
• Flash Point: 109.583°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 1-(2-bromoethoxy)-2,4-dimethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromoethoxy)-2,4-dimethylbenzene(18800-35-6)
• EPA Substance Registry System: 1-(2-bromoethoxy)-2,4-dimethylbenzene(18800-35-6)

Safety Data

• Hazardous Substances Data: 18800-35-6(Hazardous Substances Data)

Usage

General Description

1-(2-bromoethoxy)-2,4-dimethylbenzene, also known as 1-bromo-2-(2,4-dimethylphenoxy)ethane, is a chemical compound with the molecular formula C10H13BrO. It is a colorless to pale yellow liquid with a strong, sweet odor. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized as a reactive intermediate in the manufacturing of dyes and pigments. Additionally, it can be used as a solvent in various industrial processes. Although it is considered to have low toxicity, it should be handled with care and proper safety measures due to its potential for skin and eye irritation.

InChI:InChI=1/C10H13BrO/c1-8-3-4-10(9(2)7-8)12-6-5-11/h3-4,7H,5-6H2,1-2H3

Upstream product

• 106-93-4 ethylene dibromide 
• 105-67-9 2,4-Xylenol 
• 34135-75-6 2,4-dimethylphenoxyethanol 

Downstream Products

• 17349-59-6 [2-(2,4-dimethyl-phenoxy)-ethyl]-trimethyl-ammonium; bromide 
• 1352874-93-1 N-(thiazol-2-yl)-2-(4-(2-(2,4-dimethylphenoxy)ethyl)piperazin-1-yl)acetamide 
• 401797-87-3 C₁₄H₂₂N₂O 
• 55247-52-4 Benzyl-[2-(2,4-dimethyl-phenoxy)-ethyl]-amine 
• 5283-06-7 N-<2-(2.4-Dimethylphenyloxy)-ethyl>-cyclopropylamin 
• 91339-51-4 [2-(2,4-Dimethyl-phenoxy)-ethyl]-methyl-amine 
• 98155-65-8 1,2-bis-(2,4-dimethyl-phenoxy)-ethane 
• 50912-65-7 2-(2,4-dimethyl-phenoxy)-ethylamine 
• 690648-63-6 N-[2-(2,4-dimethyl-phenoxy)-ethyl]-phthalimide 

Relevant articles and documents

Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols

New derivatives of N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST), and pentylenetetrazol (PTZ) tests. Their neurotoxicity was evaluated via rotarod and chimney tests. The compounds exhibiting the most beneficial activity and protection indices were evaluated for analgesic activity using the formalin test for neurogenic pain. They were also evaluated for their influence on cytotoxic activity using in vitro cellular models (HepG2 and CRL-2534 cell lines). Experiments performed using MTT and neutral red cytotoxicity assays showed that all evaluated compounds were safe for normal, glial cells (astrocytes) and did not induce hepatotoxic effects. Based on the results from the in vitro studies, the safety of the evaluated compounds was inferred. The most promising compound in this research was 1-{2-[2-(2,3-dimethylphenoxy)ethoxy]ethyl}piperidin-3-ol hydrochloride. Additionally, in silico metabolism prediction for the compound has been performed.

A simple modification of the known preparation procedure of 2-Phenoxyethyl bromides providing high yields

A modification of preparation method was developed for synthesis of a number of 1-bromo-2-phenoxyethanes from 1,2-dibromoethanes and sodium phenolates in two-phase water-organic system with or without addition of triethylbenzylammonium chloride as phase-transfer catalyst. Addition of NaOH in two portions for transforming phenols into phenolates ensured high yields (60-80%) of phenoxylation products.