188031-47-2

Upstream product

• 188031-45-0 1-<3'-C-(tert-butyldimethylsilyloxymethyl)-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-α-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine 
• 140156-24-7 1-O-acetyl-3-C-(tert-butyldimethylsilyloxymethyl)-5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-α,β-D-erythro-pentofuranose 
• 140156-23-6 (4R,5S)-4,5-bis(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-one 
• 188031-43-8 1-<3'-C-(tert-butyldimethylsilyloxymethyl)-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-α,β-D-erythro-pentofuranosyl>cytosine 
• 88091-68-3 2-(4-nitrophenyl)ethoxycarbonyl chloride 

Relevant academic research and scientific papers

The synthesis of novel 3', 5'-homocyclic nucleotides as potential anti-HIV agents

(5S)-(5-toY-Butyldimethylsiloxymethyl)furan-2(5//)-one has been converted into cytosine 2', 3'-dideoxy-3', 5'homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.

Synthesis of the first homo-3′,5′-cyclic nucleotide

Syntheses of 2′,3′-dideoxy-3′-hydroxymethylcytidine-6′- diphenylphosphate and the corresponding 5′,6′-cyclicphenylphosphate from 5(S)-tert-butyldimethylsilyl-oxymethylfuran-2(5H)-one are achieved.