88091-68-3

Basic information

• Product Name: Carbonochloridic acid, 2-(4-nitrophenyl)ethyl ester
• CAS NO: 88091-68-3
• Molecular Formula: C9H8ClNO4
• Molecular Weight: 229.62
• Mol File: 88091-68-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbonochloridic acid, 2-(4-nitrophenyl)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonochloridic acid, 2-(4-nitrophenyl)ethyl ester(88091-68-3)
• EPA Substance Registry System: Carbonochloridic acid, 2-(4-nitrophenyl)ethyl ester(88091-68-3)

Safety Data

• Hazardous Substances Data: 88091-68-3(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 75-44-5 phosgene 

Downstream Products

• 88091-70-7 1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride 
• 88091-69-4 2'-deoxy-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine 
• 112141-37-4 3'-O-<2-(4-nitrophenyl)ethoxycarbonyl>thymidine 
• 112141-36-3 5'-O-[2-(4-nitrophenyl)ethoxycarbonyl]thymidine 
• 177084-28-5 Carbonic acid (2S,4R,5R)-4-hydroxy-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester 2-(4-nitro-phenyl)-ethyl ester 
• 188031-45-0 1-<3'-C-(tert-butyldimethylsilyloxymethyl)-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-α-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine 
• 188031-34-7 1-<3'-C-(tert-butyldimethylsilyloxymethyl)-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine 
• 259675-32-6 3',5'-di-O-acetyl-2'-deoxy-O⁶-methyl-N²-[2-(4-nitrophenyl)ethoxycarbonyl]guanosine 
• 738613-48-4 4-{[2-(4-nitrophenyl)ethoxycarbonyl]amino}-N¹-(β-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridine 
• 1414882-29-3 2'-deoxyribofuranosyl-3-guanyl-N,N-bis-[2-(4-nitrophenyl)ethoxycarbonyl]urea 
• 1414882-32-8 5'-O-dimethoxytrityl-2'-deoxyribofuranosyl-3-guanyl-N,N-bis-[2-(4-nitrophenyl)ethoxycarbonyl]urea 
• 1414882-33-9 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite 
• 1414882-31-7 5',3'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyribofuranosyl-3-guanyl-N,N-bis-[2-(4-nitrophenyl)-ethoxycarbonyl]urea 

Relevant articles and documents

Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C-H Amidation Reactions

Herein, we report the development of a tailored cobalt catalyst system of Cp*Co(III)(LX) toward intramolecular C-H nitrene insertion of azidoformates to afford cyclic carbamates. The cobalt complexes were easy to prepare and bench-stable, thus offering a convenient reaction protocol. The catalytic reactivity was significantly improved by the electronic tuning of the bidentate LX ligands, and the observed regioselectivity was rationalized by the conformational analysis and DFT calculations of the transition states. The superior performance of the newly developed cobalt catalyst system could be broadly applied to both C(sp2)-H and C(sp3)-H carbamation reactions under mild conditions.

Chemical compounds

A novel class of protecting compounds, particularly for amino acids, is based on 2,2 di nitrophenyl ethan- groups, particularly the groups wherein the nitro is in the para position. The ethyl group may be substituted, e.g. by an alkyl group, in the l- position. Preferred compounds include the alcohol or halide which are suitable for protecting acid functional groups, and esters, including activated and substituted esters, particularly the succinimidyl ester, for protecting amine groups. The invention includes methods of manufacture and use, together with protected amino acids.

THE USE OF THE p-NITROPHENYLETHOXYCARBONYL GROUP FOR AMINO PROTECTION IN CYTIDINE AND ADENOSINE CHEMISTRY

Amino protection in 2'-deoxycytidine (1) and cytidine (2) as well as in 2'-deoxyadenosine (8) and adenosine (9) respectively can be achieved by the new reagents 1-(p-nitrophenylethoxycarbonyl)-benzotriazole (3) and 1-methyl-3-(p-nitrophenylethoxycarbonyl)-imidazolium chloride (7) to from the corresponding carbamates (4, 5, 13, 14) in high yields.