18804-76-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 108-44-1 1-amino-3-methylbenzene 
• 2028-72-0 m-toluenediazonium chloride 

Downstream Products

• 112517-57-4 2-(3,5-Dinitro-benzoyl)-5-methyl-4-(m-tolyl-hydrazono)-2,4-dihydro-pyrazol-3-one 
• 70079-52-6 2-(4,6-dimethyl-pyrimidin-2-yl)-5-methyl-2H-pyrazole-3,4-dione 4-m-tolylhydrazone 
• 132576-95-5 5-Methyl-2-(pyridine-4-carbonyl)-4-(m-tolyl-hydrazono)-2,4-dihydro-pyrazol-3-one 

Relevant academic research and scientific papers

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid–leucine–arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block

Sydnones as masked hydrazines for the synthesis of 4-arylazo-1,2-dihydro- pyrazol-3-one derivatives

A simple and convenient one-pot synthesis of 4-(4-chlorophenylazo)-5- methyl-2-aryl-1,2-dihydro-pyrazol-3-ones (4a-j) has been carried out from 3-arylsydnones (3a-j) by reaction with 2-(4-chlorophenyl)-hydrazono-3-oxo- butyric acid ethyl ester (2b). The 3-arylsydnones are used as masked hydrazines in this reaction. Similarly, the 4-arylazo-2-(7-hydroxy-4-methyl-2-oxo-2H- chromen-8-ylmethyl)-5-methyl-1,2-dihydro-pyrazol-3-ones (7a-j) were synthesized from 3-[(7-acetoxy-4-methyl-8-methylene)coumaryl]sydnone (5). All the newly synthesized compounds exhibited antimicrobial activity greater than the reference drugs used. Copyright Taylor & Francis, Inc.

Synthesis, characterization and electrochemical behaviour of some substituted 3-arylazo-8-aldehydo-4-methylcoumarins at dropping mercury and glassy carbon electrodes

A series of 3-arylazo-8-aldehydo-4-methylcoumarins have been synthesized in excellent yields (80 - 90%) and their structures established on the basis of IR, 1H NMR and elemental analysis. Their purity has been ascertained by chromatographic resolution using acetic acid-toluene (6:4, v/v) as eluent. The electrochemical reduction of 3-arylazo-8-aldehydo-4-methylcoumarins have been studied over a wide pH range at dropping mercury and glassy carbon electrodes. All the compounds found to exhibit well-defined, diffusion-controlled irreversible wave. They give two-electron wave corresponding to the reduction of azo group. On the basis of cyclic voltammetry, coulometry, spectrophotometry, number of protons involved in the rate-determining step, the number of electrons in the reduction and product identification, a plausible reduction mechanism is suggested. Kinetic parameters, i.e. charge-transfer coefficient (αn) and forward rate constant (Kf,h) have also been calculated. The pK values are calculated by polarographic and spectrophotometric method.

On the Polarographic Reduction Mechanism of Some Heterocyclic Compounds

For evaluating the mechanistic steps, position at d.m.e. and assigning inner or outer sphere path of electrode processes of a number of pyrazole derivatives, thiazoles and their precursors experiments were carried out in the absence and presence of surfactants.All the compounds gave diffusion-controlled, irreversible waves over the entire pH range (2.0-11.0) studied.In presence of surfactants also, diffusion-controlled but more irreversible waves were obtained.In absence and presence of surfactant (CTAB) values of Kapp and αapp for all these compounds were calculated and have been taken as a proof of inner sphere or outer sphere path of the electrode reaction.Results have been explained on the basis of formation of phenylazo-functionalised surfactant as an intermediate species.