188048-45-5

Basic information

• Product Name: 6-[2-(6-Hydroxyheptyl)thiazol-4-yl]-4,5-dimethoxypyridine-2-carboxylic acid
• Synonyms: WS-75624B
• CAS NO: 188048-45-5
• Molecular Formula: C₁₈H₂₄N₂O₅S
• Molecular Weight: 380.46638
• Mol File: 188048-45-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-[2-(6-Hydroxyheptyl)thiazol-4-yl]-4,5-dimethoxypyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[2-(6-Hydroxyheptyl)thiazol-4-yl]-4,5-dimethoxypyridine-2-carboxylic acid(188048-45-5)
• EPA Substance Registry System: 6-[2-(6-Hydroxyheptyl)thiazol-4-yl]-4,5-dimethoxypyridine-2-carboxylic acid(188048-45-5)

Safety Data

• Hazardous Substances Data: 188048-45-5(Hazardous Substances Data)

Upstream product

• 188011-50-9 5-benzyloxy-4-methoxypyridine-2-carboxylic acid methyl ester 
• 188011-55-4 6-Acetyl-4,5-dimethoxy-pyridine-2-carboxylic acid methyl ester 
• 188011-52-1 6-Acetyl-5-hydroxy-4-methoxy-pyridine-2-carboxylic acid methyl ester 
• 742026-59-1 1,4-dihydro-4-oxo-5-(phenylmethoxy)-2-pyridinecarboxylic acid 
• 188011-51-0 5-hydroxy-4-methoxypyridine-2-carboxylic acid methyl ester 
• 188011-57-6 Acetic acid 1-methyl-6-thiocarbamoyl-hexyl ester 
• 188011-59-8 Acetic acid 6-carbamoyl-1-methyl-hexyl ester 
• 188011-58-7 7-Hydroxy-octanoic acid amide 
• 220089-82-7 6-{2-[4-(3,4-dimethoxy-pyridin-2-yl)-thiazol-2-yl]-[1,3]dithiolan-2-yl}-hexan-2-ol 
• 220089-77-0 7-[4-(3,4-dimethoxy-1-oxy-pyridin-2-yl)-thiazol-2-yl]-heptan-2-ol 
• 220089-80-5 3,4-dimethoxy-2-[2-(7-methyl-2-methylsulfanyl-oxepan-2-yl)-thiazol-4-yl]-pyridine 
• 220089-83-8 7-[4-(3,4-dimethoxy-pyridin-2-yl)-thiazol-2-yl]-heptan-2-ol 
• 220089-79-2 4-bromo-2-(7-methyl-2-methylsulfanyl-oxepan-2-yl)-thiazole 
• 220089-78-1 7-methyl-oxepane-2-thione 

Relevant articles and documents

Total synthesis of endothelin-converting enzyme antagonist WS75624 B

A concise synthesis of endothelin-converting enzyme antagonist WS75624 B is reported. The natural product was prepared in seven steps from 2,4- dibromothiazole.

Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1)

A series of bi-aryl pyridine carboxylic acids has been prepared and evaluated as inhibitors of ECE-1. The analogs were prepared by Pd catalyzed cross couplings of halogenated pyridines with heteroaryl organo -boranes, - tinate or -zincate derivatives.