188048-68-2Relevant academic research and scientific papers
Synthesis and biological activity of acylated and telomerized peptides as potential HIV-fixation inhibitors
Lacoux,Barragan,Dewynter,Leydet,Roque,Montero
, p. 767 - 773 (2007/10/03)
In order to inhibit the gp 120-CD4 glycoprotein interaction, a key step of the HIV-infection, we have synthesized a series of N-acylated peptides containing sequences identified in both the viral and lymphocytic proteins, (SDFR, SDAR, RFDSAARFDS, DRADSRRS, PSKLNDRADSRRSLWD, ASTTTNYT). An hydrophobic moiety (capryloyl, palmitoyl acrylamidoundecanoyl) was introduced in the last step of interative synthesis, in homogeneous or solid phase. The acryloyl-containing compounds were then telomerized under UV irradiation (DPn observed: 2 to 6). The biological evaluation shown an antiviral effect in vitro for telomerized peptides containing amino diacids such as Glu and Asp.
