188065-16-9Relevant academic research and scientific papers
Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists
Dorsch, Dieter,Mederski, Werner W.K.R.,Osswald, Mathias,Devant, Ralf M.,Schmitges, Claus-Jochen,Christadler, Maria,Wilm, Claudia
, p. 275 - 280 (2007/10/03)
Highly active endothelin receptor antagonists can be obtained by replacing the aryloxy group of L-749,329 by diversely substituted pyridazinone residues. The syntheses and structure-activity relationships of the new aryl-oxopyridazinyl-N-(4-arylsulfonyl)-acetamides 2 are reported. 2p with a simple dimethylpyridazinone moiety was one of the most potent compounds in vitro.
