1881-37-4

Usage

Uses

Used in Hormone Replacement Therapy:
4-fluoroestradiol is used as a hormone replacement agent for addressing hormone-dependent conditions, such as menopausal symptoms. Its high affinity for estrogen receptors makes it a promising candidate for this application.
Used in Cancer Therapy and Diagnostic Imaging:
4-fluoroestradiol is used as a targeted cancer therapy agent for estrogen receptor-positive tumors. Its high affinity for estrogen receptors allows for selective targeting of cancer cells, making it a potential candidate for both therapeutic intervention and diagnostic imaging.
Used in Pharmaceutical Industry:
4-fluoroestradiol is used as a radioligand in the pharmaceutical industry for the development of drugs targeting estrogen receptor-positive tumors. Its unique properties make it a valuable tool in the discovery and optimization of new therapeutic agents.
However, further research is needed to determine the safety and efficacy of 4-fluoroestradiol for these uses.

InChI:InChI=1/C18H23FO2/c1-18-9-8-11-10-4-6-15(20)17(19)13(10)3-2-12(11)14(18)5-7-16(18)21/h4,6,11-12,14,16,20-21H,2-3,5,7-9H2,1H3

Upstream product

• 1093411-48-3 estradiol 
• 1881-36-3 4-fluorooestrone 
• 50-28-2 estradiol 
• 1881-31-8 4-fluoro-19-nortestosterone 
• 84693-80-1 3-acetoxy-4-fluoro-16α-bromoestra-1,3,5(10)-trien-17-one 
• 84693-79-8 4-fluoroestra-1,3,5⁽¹⁰⁾,16-tetraene-3,17-diol diacetate 
• 1881-36-3 4-fluoro-3-hydroxyestra-1,3,5⁽¹⁰⁾-trien-17-one 

Relevant academic research and scientific papers

Fluorination of steroid estrogens with Selectfluor??: Elucidation of regio- and stereoselectivity

Two steroid estrogens, natural estradiol and 8?±-estradiol, were fluorinated using Selectfluor?? in ionic liquid. Unexpectedly, mostly products of fluorination at position C-10 were isolated instead of corresponding fluorophenols, as it was reported previ

Fluorination of activated aromatic systems with Selectfluor F-TEDA-BF4 in ionic liquids

Selectfluor was shown to be soluble in ionic liquid, thus allowing the 'green' electrophilic fluorination of activated aromatic systems compounds in high chemoselectivity and yields.

Efficient regioselective a-ring functionalization of oestrogens

Complete series of 2-halo- and 2-cyano-oestrogens have been prepared in good to high yields: 2-chloro, 2-bromo, 2-iodo, and 2-cyano derivatives via oestrogen-thallium (III) bis(trifluoroacetate) intermediates, and 2- and 4- fluorooestrogens by direct functionalization using N-fluoropyridinium triflate.

Direct Fluorination of Biologically Interesting Compounds Using N-Fluoro-3,5-Dichloropyridinium Triflate

N-fluoro-3,5-dichloropyridinium triflate was used for the direct fluorination of biologically important aromatic compounds.

Synthesis of 4-Fluoroestradiol Analogues

The synthesis of several 4-fluoro analogues of estradiol is described.