188174-94-9Relevant academic research and scientific papers
3-aminopyrrolidone derivatives
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Page/Page column 11, (2010/02/11)
This invention is related to compounds and use of 3-aminopyrrolidone derivatives and analogues of the following general formula (I)???whereinmis an integer from 1 to 3Xis methylene, oxygen, sulphur or a NR6 group;R1is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups;R2, R3are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups;R4, R5, R6are independently hydrogen or C1-C6 alkyl;???and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
