188247-35-0

Upstream product

• 207792-73-2 4'-Ethoxy-2-(4''-bromo-2''-nitrophenyl)acetophenone 
• 99474-21-2 (E)-2-(4-bromo-2-nitrophenyl)-N,N-dimethylethyleneamine 

Downstream Products

• 188247-38-3 2-(4 '-Ethoxyphenyl)-6-formylindole 

Relevant academic research and scientific papers

Synthesis and binding studies of a new DNA minor groove binder

2-[2′-(4″Ethoxyphenyl)-1H-indol-6′-yl]-5-(4?- methylpiperazin-1?-yl)-1H-benzimidazole (1) has been synthesized from 2-(4′-ethoxyphenyl)-1H-indole-6-carbaldehyde (4b) and 4-(4′-methylpiperazin-1′-yl)benzene-1,2-diamine (3b). The aldehyde (4b) was prepared

Radioprotectors

A compound of the formula (Ib): wherein X is NCH3, Y is N, Z is N, R3 is N(CH3)2, and (a) R1 is CH3, R2, R4 and R5 to R11 are hydrogen or (b) R5 is CH3 and R1, R2, R4 and R6 to R11 are hydrogen, and salts and tautomers thereof.

Radioprotectors

Use of a compound of formula (I): wherein X is optionally substituted aminoalkyl, optionally substituted alkylene or an interactive group; Y and Z may be the same or different and are selected from N, O, S and C(R′) wherein R′ is hydrogen, optionally substituted alkyl or optionally substituted alkenyl; ----is a double bond unless the attached Y or Z group is O or S in which case it is a single bond; and R1to R11may be the same or different and are selected from hydrogen, a sterically hindering group and an electron donating group; or any two of R1to R11, Y, Z, NH and R′ may together with the carbon atoms to which they are attached form an optionally substituted ring which may contain heteroatoms, provided that at least one of R1to R11is an electron donating group and that when X is NCH3, Y and Z are N and R1, R2and R4to R11are hydrogen, then R3is not OH or OCH2CH3; and salts thereof, pharmaceutically acceptable derivatives thereof, pro-drugs thereof and/or tautomers thereof, as a radioprotector. Also provided is a method of protecting a subject from radiation damage, a method of protecting biological materials from damage caused by radiation or cytotoxic agents and certain novel compounds of formula (I). Processes for the preparation of the novel compounds of formula (I) are also provided.

Radioprotectors

A compound of the formula: is disclosed. This compound is useful in methods of protecting a subject of of protecting biological materials from radiation damage.