188291-07-8Relevant academic research and scientific papers
Enantioselective copper catalysed intramolecular C-H insertion reactions of α-diazo-β-keto sulfones, α-diazo-β-keto phosphine oxides and 2-diazo-1,3-diketones; the influence of the carbene substituent
Shiely, Amy E.,Slattery, Catherine N.,Ford, Alan,Eccles, Kevin S.,Lawrence, Simon E.,Maguire, Anita R.
, p. 2609 - 2628 (2017)
Enantioselectivities in C-H insertion reactions, employing the copper-bis(oxazoline)-NaBARF catalyst system, leading to cyclopentanones are highest with sulfonyl substituents on the carbene carbon, and furthermore, the impact is enhanced by increased steric demand on the sulfonyl substituent (up to 91%ee). Enantioselective intramolecular C-H insertion reactions of α-diazo-β-keto phosphine oxides and 2-diazo-1,3-diketones are reported for the first time.
Asymmetric reduction of 1-methylsulfonylalkan-2-ones with baker's yeast
Maguire, Anita R.,Lowney, Declan G.
, p. 235 - 238 (2007/10/03)
Baker's yeast mediated enantioselective reduction of 1-methylsulfonylalkan-2-ones, forming the corresponding alcohols with up to 87% ee, is described.
