188304-74-7

Upstream product

• 188304-72-5 1-(tert-butyldimethylsilyl)-4-oxoazetidine-2(R)-carboxylic acid 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 220574-14-1 rac-4-[(benzyloxymethoxy)methyl]-1-(tert-butyldimethylsilyl)-azetidin-2-one 
• 337522-48-2 1-benzyl-4-(tert-butyldimethylsilyloxymethyl)azetidin-2-one 
• 610273-49-9 4-benzoyloxymethyl-N-(t-butyldimethylsilyl)-2-azetidinone 

Relevant academic research and scientific papers

Azetidinone derivatives for the treatment of HCMV infections

A compound of formula I wherein R1is hydrogen, methyl, ethyl, methoxy or methylthio; R2and R3each independently is hydrogen or lower alkyl; R4is hydrogen, lower alkyl, methoxy, ethoxy or benzyloxy; R5is lower alkyl, lower cycloalkyl, (CH2)mC(O)OR6wherein m is the integer 1 or 2 and R6is lower alkyl, phenyl optionally substituted; optionally Het or Het(lower alkyl); or R4and R5together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with C(O)O-benzyl or with phenyl optionally substituted with C(O)OR7wherein R7is lower alkyl or (lower alkyl)phenyl; and Z is lower alkyl or optionally substituted phenyl or Het; with the proviso that when Z is (CH2)p-(Het), then R2and R3each is hydrogen; or a therapeutically acceptable acid addition salt thereof which compound is useful in the treatment of HCMV infections.