188348-00-7

Basic information

• Product Name: N-BOC-D-CYCLOHEXYLGLYCINOL
• Synonyms: BOC-D-CYCLOHEXYLGLYCINOL;BOC-D-CHG-OL;N-BOC-D-CYCLOHEXYLGLYCINOL;N-T-BOC-D-CYCLOHEXYLGLYCINOL;N-T-BUTOXYCARBONYL-D-CYCLOHEXYLGLYCINOL;N-Boc-D-2-aMino-2-cyclohexyl-ethanol;tert-butyl N-[(1R)-1-cyclohexyl-2-hydroxyethyl]carbamate;-tert-Butyl (1-cyclohexyl-2-hydroxyethyl)
• CAS NO: 188348-00-7
• Molecular Formula: C₁₃H₂₅NO₃
• Molecular Weight: 243.34
• Product Categories: Amino Acid Derivatives;Amino Alcohols;Peptide Synthesis
• Mol File: 188348-00-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 83-87 °C(lit.)
• Boiling Point: 371.2 °C at 760 mmHg
• Flash Point: 178.3 °C
• Appearance: /
• Density: 1.037 g/cm³
• Vapor Pressure: 5.05E-07mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: N-BOC-D-CYCLOHEXYLGLYCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-D-CYCLOHEXYLGLYCINOL(188348-00-7)
• EPA Substance Registry System: N-BOC-D-CYCLOHEXYLGLYCINOL(188348-00-7)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-36/37/38-50/53
• Safety Statements: 26-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 188348-00-7(Hazardous Substances Data)

Usage

General Description

N-Boc-D-cyclohexylglycinol is a chemical compound with the molecular formula C12H21NO3. It is a derivative of D-cyclohexylglycine, an amino acid that is commonly used in peptide synthesis. The compound is often used as a building block in the synthesis of various peptidomimetics and pharmaceuticals due to its ability to introduce structural diversity and improve biological activities. N-Boc-D-cyclohexylglycinol also has potential applications in the development of new drug candidates and is being studied for its potential therapeutic uses in treating various diseases. Overall, this compound plays a crucial role in the field of organic chemistry and drug development.

InChI:InChI=1/C13H25NO3/c1-13(2,3)17-12(16)14-11(9-15)10-7-5-4-6-8-10/h10-11,15H,4-9H2,1-3H3,(H,14,16)/t11-/m0/s1

Upstream product

• 188348-02-9 tert-butyl (R)-(methoxycarbonyl)(cyclohexyl)methylcarbamate 
• 729559-13-1 (NE)-N-(cyclohexylmethylene)-2-methylpropane-2-sulfinamide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 849178-88-7 [1-cyclohexyl-2-(dimethyl-phenyl-silanyl)-ethyl]-carbamic acid tert-butyl ester 
• 70491-05-3 (2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid 
• 849178-79-6 2-Methyl-propane-2-sulfinic acid [(R)-1-cyclohexyl-2-(dimethyl-phenyl-silanyl)-ethyl]-amide 

Downstream Products

• 171560-20-6 (2R)-2-(1,1-dimethylethoxycarbonylamino)-2-cyclohexylethanal 
• 1227418-85-0 C₂₉H₃₈N₄O₃ 
• 1227418-73-6 C₃₀H₄₀N₄O₃ 
• 1227418-62-3 C₂₉H₄₁N₃O₃ 
• 1227418-61-2 C₂₉H₃₉N₃O₅ 
• 1227418-60-1 C₁₆H₃₀N₂O₂ 
• 1227418-59-8 C₂₁H₃₈N₂O₄ 
• 865712-55-6 (R)-2-(2-tert-butoxycarbonylamino-2-cyclohexylethoxy)-bromobenzene 
• 935878-26-5 C₂₁H₃₅N₃O₄ 
• 935878-32-3 C₁₄H₂₇NO₅S 
• 188348-02-9 tert-butyl (R)-(methoxycarbonyl)(cyclohexyl)methylcarbamate 
• 656833-28-2 (2RS,3R)-3-amino-3-cyclohexyl-2-hydroxypropanoic Acid 
• 352303-81-2 (R)-3-(N-tert-butoxycarbonyl-2-amino-2-cyclohexylethyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil 
• 352290-67-6 3-[2(R)-amino-2-cyclohexylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2,6-difluorobenzyl]-6-methyl-pyrimidine-2,4-(1H,3H)-dione 

Relevant articles and documents

Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists

Novel tricyclic indole-3-carboxamides were synthesized as structurally restricted analogs of bicyclic indoles, and found to be potent CB1 cannabinoid receptor agonists. The CB1 agonist activity depended on the absolute configuration of the chiral center of the tricyclic ring. The preferred enantiomer was more potent than the structurally unconstrained lead compound. Structure-activity relationships in the amide side chain of the indole C-3 position were also investigated.

PYRIMIDINE-2, 4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Asymmetric synthesis of 1,2-amino alcohols using tert-butanesulfinimines as chiral auxiliary

Facile and highly stereoselective synthesis of 1,2-amino alcohols has been achieved by the addition of [(dimethylphenyl-silyl)methyl] magnesium chloride to the tert-butanesulfinimines, followed by Fleming-Tamao oxidation of the silicon moiety.