188348-00-7

Usage

Uses

Used in Pharmaceutical Synthesis:
N-Boc-D-cyclohexylglycinol is used as a key building block for the synthesis of peptidomimetics and pharmaceuticals, contributing to the structural diversity and biological activity enhancement of these compounds.
Used in Drug Development:
In the pharmaceutical industry, N-Boc-D-cyclohexylglycinol is utilized as a precursor in the development of new drug candidates, exploring its potential therapeutic uses in treating a range of diseases.
Used in Organic Chemistry Research:
N-Boc-D-cyclohexylglycinol is also employed in organic chemistry for research purposes, where it aids in understanding the synthesis and properties of various organic compounds and their potential applications.

InChI:InChI=1/C13H25NO3/c1-13(2,3)17-12(16)14-11(9-15)10-7-5-4-6-8-10/h10-11,15H,4-9H2,1-3H3,(H,14,16)/t11-/m0/s1

Upstream product

• 188348-02-9 tert-butyl (R)-(methoxycarbonyl)(cyclohexyl)methylcarbamate 
• 849178-79-6 2-Methyl-propane-2-sulfinic acid [(R)-1-cyclohexyl-2-(dimethyl-phenyl-silanyl)-ethyl]-amide 
• 729559-13-1 (NE)-N-(cyclohexylmethylene)-2-methylpropane-2-sulfinamide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 849178-88-7 [1-cyclohexyl-2-(dimethyl-phenyl-silanyl)-ethyl]-carbamic acid tert-butyl ester 
• 70491-05-3 (2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid 

Downstream Products

• 171560-20-6 (2R)-2-(1,1-dimethylethoxycarbonylamino)-2-cyclohexylethanal 
• 352303-79-8 (R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-2-cyclohexylethyl)-1-(2,6-difluorobenzyl)-6-methyluracil 
• 935878-26-5 C₂₁H₃₅N₃O₄ 
• 865712-55-6 (R)-2-(2-tert-butoxycarbonylamino-2-cyclohexylethoxy)-bromobenzene 
• 1227418-85-0 C₂₉H₃₈N₄O₃ 
• 1227418-73-6 C₃₀H₄₀N₄O₃ 
• 1227418-62-3 C₂₉H₄₁N₃O₃ 
• 1227418-61-2 C₂₉H₃₉N₃O₅ 
• 1227418-60-1 C₁₆H₃₀N₂O₂ 
• 1227418-59-8 C₂₁H₃₈N₂O₄ 
• 935878-32-3 C₁₄H₂₇NO₅S 
• 188348-02-9 tert-butyl (R)-(methoxycarbonyl)(cyclohexyl)methylcarbamate 
• 656833-28-2 (2RS,3R)-3-amino-3-cyclohexyl-2-hydroxypropanoic Acid 
• 352303-81-2 (R)-3-(N-tert-butoxycarbonyl-2-amino-2-cyclohexylethyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil 

Relevant academic research and scientific papers

Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists

Novel tricyclic indole-3-carboxamides were synthesized as structurally restricted analogs of bicyclic indoles, and found to be potent CB1 cannabinoid receptor agonists. The CB1 agonist activity depended on the absolute configuration of the chiral center of the tricyclic ring. The preferred enantiomer was more potent than the structurally unconstrained lead compound. Structure-activity relationships in the amide side chain of the indole C-3 position were also investigated.

Asymmetric synthesis of 1,2-amino alcohols using tert-butanesulfinimines as chiral auxiliary

Facile and highly stereoselective synthesis of 1,2-amino alcohols has been achieved by the addition of [(dimethylphenyl-silyl)methyl] magnesium chloride to the tert-butanesulfinimines, followed by Fleming-Tamao oxidation of the silicon moiety.

PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure formula (I) wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

PYRIMIDINE-2, 4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

TRICYCLIC 1-[(3-INDOL-3-YL)CARBONYL] PIPERAZINE DERIVATIVES AS CANNABINOID CB1 RECEPTOR AGONISTS

The invention relates to tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivative having the general Formula (I) wherein X is CH2, O or S; R represents 1-3 substituents independently selected from H, (C1-4)alkyl, (C1-4)alky

3-(2-Aminoalkyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl) -6-methyluracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor

Uracils possessing N-3 side chains derived from various amino alcohols were designed and synthesized as potent human gonadotropin releasing hormone receptor antagonists. The compounds herein presented displayed superior metabolic stability than their pred

3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2

Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design allow

Chiral electrophilic 'glycinal' equivalents. New synthons for optically active α-amino acids and 4-substituted 2-oxazolidinones

The thermal reaction of 3-[(1S)-2-alkoxy-1-apocamphanecarbonyl]-2-oxazolones (21a-c) with dialkyl azodicarboxylates (9) results in exclusive formation of [4 + 2] type cycloadducts (22 and 23) with moderate levels of diastereofacial selection (up to 72% d.e.). The diastereomers thus obtained were readily purified and subsequent treatment with acidic methanol followed by removal of the auxiliary with LiBH4/MeOH (1:2) gave optically pure 4-methoxy-5-hydrazino-2-oxazolidinones (26 and 27), which serve as α-aminoaldehyde templates useful for the synthesis of a wide variety of optically active α-amino acids as well as 4-alkyl and 4-aryl-2-oxazolidinones.