1883563-86-7

Basic information

• Product Name: diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1)
• Synonyms: diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1);Tenofovir Alafenamide Impurity 2;Tenofovir Alafenamide Impurity C;diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate;TAF Impurity C;(2S,2'S)-diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))dipropanoate;2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S;2'S)-dipropionate compound with methane (1:1)
• CAS NO: 1883563-86-7
• Molecular Formula: C21H36N7O6P
• Molecular Weight: 513.53
• EINECS: -0
• Mol File: 1883563-86-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 654.6±65.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1)(1883563-86-7)
• EPA Substance Registry System: diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1)(1883563-86-7)

Safety Data

• Hazardous Substances Data: 1883563-86-7(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
Diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1) is used as an impurity in the synthesis of Tenofovir Alafenamide (T018555) for its potential role in the development of antiviral medications. The compound may be relevant in the purification and quality control processes of the final drug product, ensuring safety and efficacy.
2. Used in Research and Development:
diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1) may also be utilized in research and development settings to study its chemical properties, interactions with other molecules, and potential applications in various fields, such as materials science, pharmaceuticals, or chemical engineering. Understanding its behavior and reactivity can lead to the discovery of new compounds or processes with beneficial properties.
3. Used in Quality Control and Analysis:
In the context of pharmaceutical manufacturing, diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1) can be employed as a reference material for quality control and analytical purposes. It may be used to calibrate instruments, validate analytical methods, or establish reference standards for the detection and quantification of impurities in active pharmaceutical ingredients.

Upstream product

• 39825-33-7 isopropyl L-alanine 
• 147127-20-6 tenofovir 

Relevant articles and documents

ANTIVIRAL PHOSPHODIAMIDE COMPOUNDS

Compounds of Formula (I): and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.