188397-05-9 Usage
Uses
Used in Pharmaceutical Industry:
6-Acetyl-3-[2-(acetylaMino)ethyl]-5-Methoxy-H-indole-1-carboxylic Acid Ethyl Ester is used as a key intermediate in the preparation of 6-hydroxymelatonin, which is a human metabolite of melatonin. Melatonin is a hormone that plays a crucial role in regulating sleep-wake cycles and has various health benefits, including antioxidant and anti-inflammatory properties. The synthesis of 6-hydroxymelatonin from 6-Acetyl-3-[2-(acetylaMino)ethyl]-5-Methoxy-H-indole-1-carboxylic Acid Ethyl Ester can contribute to the development of pharmaceutical products targeting sleep disorders and other related health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 188397-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,3,9 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 188397-05:
(8*1)+(7*8)+(6*8)+(5*3)+(4*9)+(3*7)+(2*0)+(1*5)=189
189 % 10 = 9
So 188397-05-9 is a valid CAS Registry Number.
188397-05-9Relevant academic research and scientific papers
An efficient synthesis of 6-hydroxymelatonin, a human metabolite of melatonin
Karam, Omar,Zunino, Fabien,Chagnaut, Vincent,Jouannetaud, Marie Paule,Jacquesy, Jean Claude
, p. 1511 - 1513 (2007/10/03)
A four-step synthesis of 6-hydroxymelatonin 5, major human metabolite of melatonin 1, is reported starting from melatonin. The synthesis involves in the keys steps a regioselective Friedel-Crafts acylation followed by a Baeyer-Villiger oxidation. The overall yield is 48%.
Acylated derivatives of melationin and its analogues, useful as medicaments
-
, (2008/06/13)
The invention relates to derivatives of general formula I STR1 as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in particular or the treatment of complaints associated with melatonin disorders, and pharmaceutical and cosmetic compositions comprising them.
