1884-42-0

Basic information

• Product Name: 1-(3-METHOXYPHENYL)CYCLOHEXANOL
• Synonyms: 1-(3-METHOXYPHENYL)CYCLOHEXANOL;Tramadol Impurity 1
• CAS NO: 1884-42-0
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.28
• Mol File: 1884-42-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3-METHOXYPHENYL)CYCLOHEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-METHOXYPHENYL)CYCLOHEXANOL(1884-42-0)
• EPA Substance Registry System: 1-(3-METHOXYPHENYL)CYCLOHEXANOL(1884-42-0)

Safety Data

• Hazardous Substances Data: 1884-42-0(Hazardous Substances Data)

Usage

Uses

1-(3-Methoxyphenyl)cyclohexanol can react with the NMDA receptor coupled PCP-binding which can make it effective at treating different forms of cancer.

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 108-94-1 cyclohexanone 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 10365-98-7 3-methoxyphenylboronic acid 

Downstream Products

• 43050-17-5 (+/-)-1-(3-Methoxy-phenyl)-7-oxa-bicyclo[4.1.0]heptane 
• 43050-31-3 2-(3-methoxyphenyl)cyclohex-2-en-1-ol 
• 125802-07-5 1-(3-methoxyphenyl)cyclohexan-1-amine 
• 1884-41-9 1-Cyclohex-1-enyl-3-methoxy-benzene 
• 706793-32-0 1-(1-azidocyclohexyl)-3-(methyloxy)benzene 

Relevant articles and documents

BACE-2 INHIBITORY COMPOUNDS AND RELATED METHODS OF USE

Provided herein are novel compounds of Formulae I-III, and methods of using the same to selectively inhibit BACE2.

Synthesis of methoxetamine, its metabolites and deuterium labelled analog as analytical standards and their HPLC and chiral capillary electrophoresis separation

Methoxetamine, a designer drug marketed as a replacement for the dissociative anaesthetic ketamine, has been associated with significant numbers of hospital related intoxications and deaths in Europe. The fast and user-friendly identification and quantification of methoxetamine and its metabolites is a key factor for successful treatment of intoxication. Therefore, we suggested a convenient preparation method which was used for the synthesis of methoxetamine, seven methoxetamine metabolites and a deuterium labelled derivative as analytical standards. Methoxetamine and normethoxetamine were used as starting materials for the preparation of O-demethylated and N-dealkylated metabolites. The multistep synthesis starts from commercially available compounds and offers good yields. Our prepared analytical standards were used for the confirmation of the suggested structure of methoxetamine metabolites in rat urine by LCMS. Capillary electrophoresis was used for the chiral separation of MXE and its metabolites using β-cyclodextrin, carboxymethylated β-cyclodextrin, and sulphated β-cyclodextrin as chiral selectors at various concentrations. Chiral separation was successful for four analytes. A mixture of MXE and its metabolites was subsequently analyzed under optimal conditions, i.e. when using 15 mmol L-1 β-cyclodextrin in 50 mmol L-1 phosphate buffer, pH 2.5. In this case, chiral separation was achieved for three analytes and all analytes were separated from each other.

Synthesis and application of 2,6-bis(trifluoromethyl)-4-pyridyl phosphanes: The most electron-poor aryl phosphanes with moderate bulkiness

The poor will be rich: BFPy phosphanes (see scheme) mimic the electronic and steric characters of P(C6F5)3 and PPh 3, respectively. These novel ligands showed a large ligand acceleration effect on Stille coupling, the Rh-catalyzed 1,2-addition of aryl boronic acid to unactivated ketones and the asymmetric arylation of N-tosylimine using phenylboronic acid. Copyright