1884-86-2

Basic information

• Product Name: (1S,2S)-1-(4-nitrophenyl)-2-phthalimido-1,3-propanediol
• Synonyms: (1S,2S)-1-(4-nitrophenyl)-2-phthalimido-1,3-propanediol
• CAS NO: 1884-86-2
• Molecular Weight: 342.308
• Mol File: 1884-86-2.mol

Chemical Properties

• CAS DataBase Reference: (1S,2S)-1-(4-nitrophenyl)-2-phthalimido-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-1-(4-nitrophenyl)-2-phthalimido-1,3-propanediol(1884-86-2)
• EPA Substance Registry System: (1S,2S)-1-(4-nitrophenyl)-2-phthalimido-1,3-propanediol(1884-86-2)

Safety Data

• Hazardous Substances Data: 1884-86-2(Hazardous Substances Data)

Upstream product

• 22509-74-6 N-ethoxycarbonylphthalimide 
• 119-62-0 (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 
• 85-44-9 phthalic anhydride 

Downstream Products

• 130042-72-7 (1S,2S)-1-acetoxy-1-(4-nitrophenyl)-3-bromo-2-phthalimidopropane 
• 129048-03-9 (1S,2S)-1-acetoxy-1-(4-nitrophenyl)-3-iodo-2-phthalimidopropane 
• 2153-98-2 (-)-Norpseudoephedrine hydrochloride 
• 59686-10-1 1-phenyl-2-phthalimido-1-propanol 
• 123537-85-9 (1S,2S)-1-acetoxy-1-phenyl-2-phthalimido-propane 
• 130873-80-2 (1S,2S)-1,3-dihydroxy-1-phenyl-prop-2-yl-ammonium chloride 
• 123475-39-8 (1S,2S)-1-hydroxy-1-phenyl-2-phthalimido-3-tosyloxy-propane 
• 123475-40-1 (1S,2S)-1-acetoxy-1-phenyl-3-iodo-2-phthalimidopropane 
• 123537-84-8 (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol 
• 191418-46-9 (2S)-1-(p-nitrophenyl)-2-phthalimido-3-phenylacetoxy-1-propanone 
• 191418-20-9 (2S)-1-(p-nitrophenyl)-2-phthalimido-3-propionyloxy-1-propanone 
• 191418-43-6 (2S)-1-(p-nitrophenyl)-2-phthalimido-3-acetoxy-1-propanone 
• 102809-77-8 1-(p-nitrophenyl)-2,3-di(phthalimido)-propanone 
• 63457-11-4 (2S)-1-(p-nitrophenyl)-2-phthalimido-2-propen-1-one 

Relevant articles and documents

2-amino-1-phenyl-propan-1,3-diol as chiral auxiliary. Application in the synthesis of cis 3-phthalimido-4-styryl-2-azetidinones

3,4-cis3,4-cis-1-N-(1'-phenyl-1',3'-dihydroxy-2'-propyl)-3-phthalimido-4 -styrylazetidinones were obtained in optically pure form by chiral Staudinger reaction. The cis-α/β-ratio could be influenced by the protective groups of the diol moiety. Removal of the chiral auxiliarity could be accomplished by direct oxidation, or by previous double bond formation, thus the 2-amino-1-phenyl-propan-1,3-diol can be regarded to a generally useful chiral auxiliary.

(1S,2S)-2-Amino-1-aryl-propane-1,3-diols as Convenient Educts for the Synthesis of Homochiral (S,S)-Norpseudoephedrine

A convenient high yield synthesis of homochiral norpseudoephedrine starting from waste products of the chloramphenicol synthesis is described as an example of its utilization in chemical transformations.