59686-10-1

Upstream product

• 19437-20-8 N-((R)-1-methyl-2-oxo-2-phenyl-ethyl)-phthalimide 
• 53100-40-6 (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride 
• 59146-03-1 N-((S)-1-methyl-2-oxo-2-phenyl-ethyl)-phthalimide 
• 160857-12-5 Thioacetic acid S-[(2R,3S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-3-phenyl-propyl] ester 
• 85-44-9 phthalic anhydride 
• 4306-25-6 (S)-2-phthalimidopropionyl chloride 
• 71-43-2 benzene 
• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 123475-38-7 (1S,2S)-1(4-aminophenyl)-2-phthalimido-propane-1,3-diol 
• 123475-39-8 (1S,2S)-1-hydroxy-1-phenyl-2-phthalimido-3-tosyloxy-propane 
• 1884-86-2 (1S,2S)-1-(4-nitrophenyl)-2-phthalimido-1,3-propanediol 
• 123475-40-1 (1S,2S)-1-acetoxy-1-phenyl-3-iodo-2-phthalimidopropane 
• 119-62-0 (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 
• 123537-84-8 (1S,2S)-1-phenyl-2-phthalimido-propane-1,3-diol 

Downstream Products

• 130873-80-2 (1S,2S)-1,3-dihydroxy-1-phenyl-prop-2-yl-ammonium chloride 
• 2153-98-2 (-)-Norpseudoephedrine hydrochloride 

Relevant academic research and scientific papers

Process for the preparation of optically active amino alcohols

Process for preparing optically active β-amino alcohols represented by a general formula (2): Ra—C*H(OH)—C*H(Rb)—Rc wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, Rb is one member select

Reaction of (1S,2S)-2-amino-1-phenyl-1,3-propanediol with thioacids under the Mitsunobu reaction condition

The Mitsunobu thioesterification was applied to the title 2-amino-1,3-propanediol (1). The regio- and stereochemistry of the reaction was investigated in correlation with the nature of substituents attached to the nitrogen.

(1S,2S)-2-Amino-1-aryl-propane-1,3-diols as Convenient Educts for the Synthesis of Homochiral (S,S)-Norpseudoephedrine

A convenient high yield synthesis of homochiral norpseudoephedrine starting from waste products of the chloramphenicol synthesis is described as an example of its utilization in chemical transformations.