18847-18-2

Usage

InChI:InChI=1/C14H18O3/c1-10(2)11-6-8-12(9-7-11)13(15)4-3-5-14(16)17/h6-10H,3-5H2,1-2H3,(H,16,17)

Upstream product

• 108-55-4 glutaric anhydride, 
• 98-82-8 Isopropylbenzene 

Downstream Products

• 1584137-64-3 6-(4-isopropylphenyl)hexan-2-ol 
• 1216244-91-5 C₁₄H₂₂O 
• 1310312-76-5 5-(4-isopropylphenyl)pentanal 
• 870286-96-7 5-(4-isopropyl-phenyl)-5-oxo-pentanoic acid sodium salt 
• 18108-50-4 γ-<2-Aethyl-4-ispropyl-phenyl>-buttersaeure 
• 18108-46-8 δ--valeriansaeure 

Relevant academic research and scientific papers

Iron-catalyzed arene alkylation reactions with unactivated secondary alcohols

A simple, iron-based catalytic system allows for the inter- and intramolecular arylation of unactivated secondary alcohols. This transformation expands the substrate scope beyond the previously required activated alcohols and proceeds under mild reaction conditions, tolerating air and moisture. Furthermore, the use of an enantioenriched secondary alcohol provides an enantioenriched product for the intramolecular reaction, thereby offering a convenient approach to nonracemic products.

Hypervalent iodine(III) sulfonate mediated synthesis of 5-benzoyldihydro-2(3H)-furan-one in ionic solvent

The room temperature ionic liquid, n-butylpyridinium tetrafluoroborate(BPyBF4) is used as a "green" recyclable solvent for the reaction of 4-benzoylbutyric acid with [hydroxy-(2,4-dinitrobenzenesulfonyloxy)iodo]-benzene (HDNIB) to prepare 5-benzoyldihydro-2(3H)-furanone.

ON THE QUANTITATIVE RELATIONS BETWEEN STRUCTURE AND ANTIAGGREGATION ACTIVITY OF ω-ARYL-ω-OXOALKANOIC ACIDS

A series of ω-aryl-ω-oxoalkanoic acids, I-IV, has been prepared and investigated for dissociation constants in 80percent methylcellosolve, retention characteristics in thin-layer partition chromatography and partition coefficients P in the system octanol-water.Also evaluated were their anti-inflammatory efficacy and inhibitory effect on the platelet aggregation induced by collagen.Analysing the relations between structure and antiaggregation effect, we obtained a non-linear, quadratic dependence of this effect on lipophilicity, the optimum being at log P = 3.The antiaggregation effect increased with shortening the chain between the carbonyl and the carboxyl, and with increasing acidity.It was also diminished by the presence of a methyl group on the interlinking chain.To assess the role of lipophilicity we used the RM values of partition chromatography.The relation between anti-inflammatory efficacy and structure was assessed only qualitatively.In this aspect, too, the nature of the chain between the carbonyl and carboxyl proved to have a marked influence.The anti-inflammatory activity proved considerably enhanced by the presence of another aromatic ring in ω-oxoalkanoic acids derived from biphenyl.