188472-65-3

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 188472-64-2 (1R,6S)-3-Methyl-6-(2-trimethylsilanyl-furan-3-yl)-4,6-bis-trimethylsilanyloxy-cyclohex-3-enecarboxylic acid ethyl ester 
• 129313-41-3 Ethyl (1R,2S,4S,5S)-2-hydroxy-4-<(2S)-2-hydroxy-2-phenylacetoxy>-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate 
• 114047-83-5 Ethyl (1R,2S,5S)-2-hydroxy-5-methyl-4-oxo-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate 
• 129312-19-2 Ethyl (1R,2S,4S,5S)-2,4-dihydroxy-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate 

Downstream Products

• 114047-84-6 Ethyl (1R,4S,6S)-2,6-dihydroxy-3-methyl-6-(2-trimethylsilyl-3-furyl)cyclohex-2-enecarboxylate 
• 129263-84-9 Ethyl (1R,4S,6S)-6-hydroxy-4-methoxy-3-methyl-6-(2-trimethylsilyl-3-furyl)cyclohex-2-enecarboxylate 
• 129245-44-9 (1R,2S,5R)-2-Hydroxy-5-methyl-4-oxo-5-phenylselanyl-2-(2-trimethylsilanyl-furan-3-yl)-cyclohexanecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Total synthesis of milbemycin E: Resolution of the C(1)-C(10) fragment and final assembly

The racemic hydroxycyclohexanone (±)-7, prepared by the Robinson addition of the keto ester 5 to 3-methylbut-3-enone 6, has been reduced stereoselectively to give the racemic cyclohexanediol (±)-8. This has been resolved by fractional crystallisation of t