188497-71-4Relevant academic research and scientific papers
Tetrahydrofolic acid Is a potent suicide substrate of mushroom tyrosinase
Garcia-Molina, Francisco,Munoz-Munoz, Jose Luis,Martinez-Ortiz, Francisco,Garcia-Ruiz, Pedro Antonio,Tudela, Jose,Garcia-Canovas, Francisco,Rodriguez-Lopez, Jose Neptuno
, p. 1383 - 1391 (2011)
The coenzyme tetrahydrofolic acid is the most rapid suicide substrate of tyrosinase that has been characterized to date. A kinetic study of the suicide inactivation process provides the kinetic constants that characterize it: λmax, the maximum apparent inactivation constant; r, the partition ratio or the number of turnovers made by one enzyme molecule before inactivation; and κcat and Km, the catalytic and Michaelis constants, respectively. From these values, it is possible to establish the ratio ?max/Km, which represents the potency of the inactivation process. Besides acting as a suicide substrate of tyrosinase, tetrahydrofolic acid reduces o-quinones generated by the enzyme in its action on substrates, such as l-tyrosine and l-DOPA (o-dopaquinone), thus inhibiting enzymatic browning.
Stabilized aqueous folic acid preparation
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, (2008/06/13)
This invention relates to a stabilized aqueous folic acid preparation which comprises a folic acid component selected from the group consisting of folic acid, ammonium, alkali metal and alkaline earth metal salts of folic acid and mixtures thereof, and which has an improved stability of its folic acid contents in the presence of oxygen, the said preparation containing as a stabilizer a combination of (a) at least one member selected from the group consisting of dihydrofolic acid and ammonium, alkali metal, alkaline earth metal and alkanolammonium salts thereof, and (b) at least one member selected from the group consisting of at least one hydroxypolycarboxylic acid and ammonium, alkali metal, alkaline earth metal and alkanolammonium salts thereof.
