18852-14-7Relevant academic research and scientific papers
TEN-MEMBERED CYCLOTRIPEPTIDES: INFLUENCE OF THE RING-FLEXIBILITY ON INTRAMOLECULAR REACTIONS
Pinnen, F.,Zanotti, G.,Lucente, G.
, p. 5201 - 5204 (2007/10/02)
Cyclization of different models of linear precursors of 10-membered cyclotripeptides is described.Macrocyclic compounds, aza-cyclols, N-acyl-diketopiperazines and acylamidines were isolated and their formation related to the flexibility of the ring.
Cyanic Acid Ester. 35. On Formation and Consecutive Reactions of N-Cyanato Phthalimide. New Specifically Activated and Blocked Isatoic Acid Derivatives
Martin, Dieter,Nadolski, Karin,Gruendemann, Egon
, p. 737 - 746 (2007/10/02)
Depending on the reaction conditions N-hydroxy-phthalimide affords on treatment with cyanogen bromide via N-cyanato phthalimide 2 the iminocarbonate 3 and isatoic acid derivatives 7 and 16.Both the latter react with nucleophiles as isatoic acid derivatives activated on the carboxylic group and protected on the carbamic group or vice versa, furnishing N,N-bis alkoxycarbonyl anthranilic acid amides 9, N-alkoxycarbonyl anthranilic acid 12, o-alkoxycarbonyl phenyl ureas 17 and the benzotriazepin-2,5-dione 14.The structures of the new compounds are proved by 1H-n.m.r. and 13C-n.m.r. measurements as well as independent synthesis.
