188524-64-3

Basic information

• Product Name: (E)-methyl 3-(1-benzyl-1H-indol-3-yl)acrylate
• Synonyms: (E)-methyl 3-(1-benzyl-1H-indol-3-yl)acrylate
• CAS NO: 188524-64-3
• Molecular Weight: 291.349
• Mol File: 188524-64-3.mol

Chemical Properties

• CAS DataBase Reference: (E)-methyl 3-(1-benzyl-1H-indol-3-yl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 3-(1-benzyl-1H-indol-3-yl)acrylate(188524-64-3)
• EPA Substance Registry System: (E)-methyl 3-(1-benzyl-1H-indol-3-yl)acrylate(188524-64-3)

Safety Data

• Hazardous Substances Data: 188524-64-3(Hazardous Substances Data)

Upstream product

• 10511-51-0 1-Benzylindole-3-carboxaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 19626-92-7 trans-3-(3-indolyl)acrylsaeuremethylester 
• 1204-06-4 trans-3-indole-acrylic acid 
• 3377-71-7 N-benzylindole 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 1407499-64-2 (E)-N'-(3-(1-benzyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1027170-80-4 4-(1-Benzyl-1H-indol-3-yl)-1H-pyrrole-3-carboxylic acid 

Relevant articles and documents

Non-redox metal ion promoted oxidative coupling of indoles with olefins by the palladium(II) acetate catalyst through dioxygen activation: Experimental results with DFT calculations

Developing new catalytic technologies through C-H bond activation to synthesize versatile pharmaceuticals has attracted much attention in recent decades. This work introduces a new strategy in catalyst design for Pd(ii)-catalyzed C-H bond activation in wh

Transition-Metal-Free Stereocomplementary Cross-Coupling of Diols with Boronic Acids as Nucleophiles

The transition-metal-free diastereoselective C(sp2)-C(sp3) cross-coupling between unprotected diols and boronic acids or potassium organotrifluoroborates is reported. Depending on the reaction conditions, the syn or the anti reaction products are obtained in a stereocomplementary fashion. This type of coupling is developed with alkenyl-, heteroaryl- and arylboron compounds as carbon nucleophiles.

Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors

A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.

Directed palladation: Fine tuning permits the catalytic 2-alkenylation of indoles

A C-H activating Pd-catalysed alkenylation of indole is regiospeciflc for 2-substitution when the nitrogen carries a 2-pyridylmethyl substituent. The Royal Society of Chemistry 2005.