188527-08-4

Basic information

• Product Name: N-Benzyl 1-BOC-piperidine-4-carboxaMide
• Synonyms: N-Benzyl 1-BOC-piperidine-4-carboxaMide;N-benzyl-1-(tert-butoxycarbonyl)piperidine-4-carboxamide
• CAS NO: 188527-08-4
• Molecular Formula: C₁₈H₂₆N₂O₃
• Molecular Weight: 318.41064
• Mol File: 188527-08-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Benzyl 1-BOC-piperidine-4-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl 1-BOC-piperidine-4-carboxaMide(188527-08-4)
• EPA Substance Registry System: N-Benzyl 1-BOC-piperidine-4-carboxaMide(188527-08-4)

Safety Data

• Hazardous Substances Data: 188527-08-4(Hazardous Substances Data)

Usage

General Description

N-Benzyl 1-BOC-piperidine-4-carboxamide is a chemical compound with the molecular formula C20H27NO3. It is a derivative of piperidine and contains a benzyl and BOC (tert-butoxycarbonyl) group attached to the nitrogen and carbon atoms of the piperidine ring, respectively. N-Benzyl 1-BOC-piperidine-4-carboxaMide is commonly used as a building block in organic synthesis for the preparation of various pharmaceutical and agrochemical products. It is also used as a protecting group for amines, enabling selective functionalization of other reactive sites in complex organic molecules. N-Benzyl 1-BOC-piperidine-4-carboxamide has applications in medicinal chemistry and drug discovery, and its versatility makes it a valuable tool for chemical research and development.

Upstream product

• 100-46-9 benzylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 498-94-2 isonipecotic acid 
• 280115-99-3 tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 

Downstream Products

• 320420-00-6 N-(phenylmethyl)-4-piperidinecarboxamide hydrochloride 
• 101264-48-6 4-(phenylmethylaminocarbonyl)piperidine 
• 896085-01-1 tert-butyl 4-(benzyl(ethyl)carbamoyl)piperidine-1-carboxylate 
• 6308-67-4 N-benzyl-N-ethylpiperidine-4-carboxamide hydrochloride 
• 1401618-93-6 N-benzyl-1-(1-(4-chlorobenzyl)-1H-imidazole-2-carbonyl)piperidine-4-carboxamide 

Relevant articles and documents

Mitochondrial Cl--Selective Fluorescent Probe for Biological Applications

Herein we describe the development of the first mitochondrial Cl-selective fluorescent probe, Mito-MQAE, and its applications in biological systems. Fluorescence of Mito-MQAE is insensitive to pH over the physiological pH range and is quenched by Cl- with a Stern-Volmer quenching constant of 201 M-1 at pH 7.0. The results of cell studies using Mito-MQAE show that substances with the ability to disrupt mitochondrial membranes cause increases in the mitochondrial Cl- concentration.

NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS

The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS

Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.