188529-34-2

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 152178-79-5 5-acetamido-2,6-anhydro-4-azido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid methyl ester 
• 188529-20-6 (4S,5R,6R)-5-acetylamino-4-azido-6-[(S)-hydroxy-(2-oxo-[1,3]dioxolan-4R-yl)-methyl]-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester 

Downstream Products

• 1054665-48-3 4-Phenylacetyl-piperazine-1-carboxylic acid (S)-((2R,3R,4S)-3-acetylamino-4-azido-6-methoxycarbonyl-3,4-dihydro-2H-pyran-2-yl)-((R)-2-oxo-[1,3]dioxolan-4-yl)-methyl ester 

Relevant academic research and scientific papers

Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain

Analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) have been prepared containing carbamate substituents at the 7-hydroxy position. (4S,5R,6R)-5- Acetylamino-6-{1R-[(6-aminohexyl)carbamoyloxy]-2R,3-dihydroxypropyl}-4- guanidino-5,6-dihydro-4H-pyran-2carboxylic acid and (4S,5R,6R)-5-Acetylamino- 6-{1R-[heptylcarbamoyloxy]-2R,3-dihydroxypropyl}-4-guanidino-5,6-dihydro4H- pyran2-carboxylic acid were the two analogues possessing activity comparable to Zanamivir, showing potent inhibition of influenza virus sialidases and good antiviral activity in vitro.

Dihydropyran derivatives as viral neuraminidase inhibitors

Compounds of formula (I), wherein R1 represents NR5 R6, wherein R5 represents H or a hydrocarbon group optionally substituted by one or more of Br, Cl, F, I, CF3, NR7 R8, CO