188532-21-0

Basic information

• Product Name: 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-mercapto-propionamide
• Synonyms: 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-mercapto-propionamide
• CAS NO: 188532-21-0
• Molecular Weight: 309.473
• Mol File: 188532-21-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-mercapto-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-mercapto-propionamide(188532-21-0)
• EPA Substance Registry System: 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-mercapto-propionamide(188532-21-0)

Safety Data

• Hazardous Substances Data: 188532-21-0(Hazardous Substances Data)

Upstream product

• 107902-68-1 5-{[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-methyl}-2-thioxo-4-thiazolidinone 
• 67739-23-5 5-(4-hydroxy-3,5-di-tert-butylbenzylidene)rhodanine 

Downstream Products

• 107902-69-2 4-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-[1,3]oxathiolan-5-one 
• 107902-67-0 tazofelone 
• 188532-24-3 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-hydroxymethylsulfanyl-propionamide 

Relevant articles and documents

The development of a manufacturable synthesis of LY213829

The development of a manufacturable synthesis of LY213829 (4-thiazolidinone-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl] methyl) is described. Rather than reduction to eliminate the thiocarbonyl from the rhodanine moiety, the new route utilizes a novel

Product structure as a function of reaction conditions in the reaction of formaldehyde with an alpha-mercapto amide

Treatment of mercapto amide (3) with formaldehyde and acid or base results in products whose structures are a function of the reaction conditions. Lactone (8), hemithioacetal (9), and dimer (7) were formed in good yields under acidic reaction conditions.