188532-26-5

Basic information

• Product Name: 2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-
• CAS NO: 188532-26-5
• Molecular Formula: C18H25NO3S
• Molecular Weight: 335.467
• Mol File: 188532-26-5.mol

Chemical Properties

• CAS DataBase Reference: 2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-(188532-26-5)
• EPA Substance Registry System: 2,4-Thiazolidinedione, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-(188532-26-5)

Safety Data

• Hazardous Substances Data: 188532-26-5(Hazardous Substances Data)

Usage

Chemical class

Thiazolidinedione

Medical use

Treatment of type 2 diabetes

Mechanism of action

Increases body's sensitivity to insulin, helping to lower blood sugar levels

Structural features

Contains a phenyl group with hydroxyl and tert-butyl substituents

Pharmacological properties

May contribute to therapeutic effects

Safety

Should only be used under the supervision of a healthcare professional

Potential side effects

May have potential side effects and interactions with other medications.

Upstream product

• 331622-92-5 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2,4-thiazolidinedione 
• 127378-46-5 darbufalone 
• 1620-98-0 3,5-di-t-butyl-4-hydroxybenzaldehyde 
• 154052-44-5 (Z)-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-2,4-thiazolidinedione 

Downstream Products

• 107902-67-0 tazofelone 

Relevant articles and documents

THIAZOLIDINEDIONE COMPOUNDS FOR TREATMENT OF DRUG RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA

Cell death may be induced in a cancer cell line, by treating the cancer cell line with a compound of formula (I), a compound of formula (II), pharmaceutically acceptable salts thereof, mixtures thereof, enantiomers thereof, or racemates thereof: wherein X

Regiospecific reduction of 5-benzylidene-2,4-thiazolidinediones and 4- oxo-2-thiazolidinethiones using lithium borohydride in pyridine and tetrahydrofuran

The novel regiospecific and general reduction of 5-benzylidene-2,4- thiazolidinediones and 5-benzylidene-4-oxo-2-thiazolidinethiones to the corresponding 5-benzyl derivatives has been accomplished using lithium borohydride in pyridine and tetrahydrofuran. Sodium borohydride and lithium chloride can also be used under these conditions, which represents a cheaper alternative to lithium borohydride. (C) 2000 Elsevier Science Ltd.

Process for preparing benzyl-substituted rhodanine derivatives

The instant invention provides a novel process for preparing benzyl-substituted rhodanine derivatives. Also provided are novel benzyl-substituted thiolamides and benzyl-substituted hemithioacetals. Such compounds are useful as intermediates in preparing t